Lethal Dose


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Related to Lethal Dose: therapeutic index, Lethal Dose 50

Lethal Dose

 

a dose of any chemical or physical agent that brings about the death of a living organism.

Lethal doses are determined in animal experiments for various pharmacological agents, pesticides, and ionizing radiation. Lethal doses vary both with the properties of the agents and with the age, condition, and individual sensitivity of the organism. Therefore, lethal doses must be determined experimentally on a fairly representative number of animals. A distinction is made between minimum lethal dose, which is fatal only to the most sensitive individuals of a species (no more than 10 percent of the experimental animals); median lethal dose, which is fatal to half (LD50) the animals; and absolute lethal dose, which is the smallest amount that will cause the death of all of the experimental animals (LD100).

References in periodicals archive ?
neotropicus as previously described were placed on arenas sprayed with increasing lethal doses ([LD.
When his illness eventually got to be too much to bear, he asked Brendan to give him a lethal dose, to take him out of his misery.
Under Oregon law only a mentally competent person with six months or less to live can obtain a prescription for a lethal dose of barbiturates.
A LOCUM doctor, who gave a lethal dose of morphine several times the recommended level to a pensioner,did so because of his patient's weight, a court heard yesterday.
James Bird, 20, was found dead in his room at his Cardiff hall of residence surrounded by scribbled notes and equations showing how he had worked out the lethal dose.
This dose is about one-fourth the median lethal dose for rats.
The measure allows a physician to prescribe a lethal dose of medication when conditions of the act are met.
Murray is accused of giving a lethal dose of the anaesthetic and a cocktail of other sedatives.
She stole Syntometrine from hospital and then accused her midwife of injecting the lethal dose.
Mystery still surrounds the death of a pensioner who swallowed a lethal dose of sleeping tablets.
The news comes after bullied Wirral schoolboy Thomas Thompson took a lethal dose of pain killers at his home.
A TEENAGER was fighting for his life last night after taking a potentially lethal dose of the drug amphetamine.