is a malignancy of hematologic origin, occurring from either disorganized proliferation or increased life span of white cells (now called blasts).
Acute myeloid leukemia
is characterized by an overproduction of immature white blood cells that fail to mature properly.
Conclusion: Aberrant CD markers expression must be kept in mind during lineage assignment of acute leukemias
while performing flow cytometric immunophenotyping.
Results: Of a total 145 cases analyzed, 26 were acute myeloid leukemia
, 71 of acute lymphoblastic leukaemia, 48 were of Chronic Lymphoid leukemia
on the basis of morphological features and confirmed by flow cytometry.
Among the leukemias
, AML is the most common malignant disorder and it counts as major cause of bicytopenia and pancytopenia in the bone marrow studies performed.
The first consensus method for identifying MPAL was the algorithm proposed by the European Group for Immunological Characterization of Acute Leukemias
(EGIL) in 1995.
Biomedical testing company Beckman Coulter Inc stated on Thursday that the US Food and Drug Administration has allowed the marketing of the first ClearLLab Reagents (T1, T2, B1, B2, M) test for use with flow cytometry to aid in the detection of several leukemias
Specifically, for patients with leukemia
, the word blast has a very unfavorable and potentially devastating connotation.
(8) Abnormalities of chromosome 12p have also been identified in 5 percent of cases of acute nonlymphocytic leukemias
(ANLL) and myelodysplastic syndromes (MDS).
INTRODUCTION: Acute leukemias
are a heterogeneous group of malignancies with varying clinical, morphological, immunological and molecular characteristics.
grow quickly and require immediate and aggressive treatment.