P value ESR smokers (mm/h) 10.778 1.524 0.006 ESR non-smokers (mm/h) 1.602 0.227 0.006 TLC of smokers (per [mm.sup.3]) 1879.562 265.810 0.0001 TLC of non-smokers (per [mm.sup.3]) 34862.03 176.128 0.0001 Age of smokers (years) 4.168 0.3805 0.0646 Age of non-smokers (years) 4.911 0.4483 0.0646 ESR: Erythrocyte sedimentation rate, TLC: Total leukocyte count
, mm/h: Millimeter/hour, Min: Minimum, Max: Maximum, SD: Standard deviation, S E: Standard error, n: Sample size
By univariable analysis (Table 2), the factors significantly associated with the occurrence of severe NE were nephrotoxic drug intake, visual disorders, hematuria, leukocyte count
>10 x [10.sup.9] cells/L, C-reactive protein >100 mg/L (>952 nmol/L), and thrombocytopenia [less than or equal to]90 x [10.sup.9]/L.
LAD is an attractive disease for human gene therapy as the conventional therapy with antibiotics and granulocytes transfusions improves the symptoms only but does not correct the phenotype.10 The only definite treatment is stem cell or bone marrow transplantation from histocompatible relatives and should be considered as an early therapeutic option if a suitable HLA-matched stem-cell donation is available.9 Our cases emphasize that as physicians we should investigate any child presenting with delayed umbilical cord separation and markedly raised leukocyte count
. Detail immunological assessment is also needed with management aimed at treating infections, hygiene, and antibiotic prophylaxis with age appropriate immunizations.
Analyses of HbA1c levels, leukocyte count
, and serum creatinine levels were described in Tables 2, 3, and 4.
Studies have shown that increased leukocyte counts
are reliable markers of systemic inflammation and have diagnostic as well as prognostic value in patients of angina, myocardial infarction, stroke, peripheral vascular disease and micro and macro vascular complication associated with diabetes.3,4
Table 1: Haematobiochemical parameters Parameters Value Reference range Haemoglobin (g/dL) 13.5 8-15 PCV (%) 35 24-46 Total leukocyte count
(per cmm) 14000 4000-12000 Neutrophil (%) 71 6-40 Lymphocyte (%) 26 25-75 Serum protein (g/dL) 7.48 3.74-7.46 Serum albumin (g/dL) 1.45 3.03-3.55 Serum calcium (mEq/L) 9 9.7-12.4 Serum sodium (mEq/L) 139 132-152 Serum potassium (mEq/L) 3.7 3.9-5.8 Serum chloride (mEq/L) 97 97-111 Serum phosphrous (mEq/L) 4 5.6-6.5
Other studies ([6,13,14]) have shown that high leukocyte counts
are a predictor of VTE in patients with myeloproliferative disorders, but, in patients without such diseases, there is few data available and the mechanism is not known.
Conclusion: Raised leukocyte count
was found to have high sensitivity but low specificity for diagnosing acute appendicitis.
An arthrocentesis of the knee revealed turbulent fluid and a leukocyte count
of 75,250 31/[mm.sup.3].
Moreover, laboratory data, which included leukocyte counts
, haemoglobin, platelets, and C-reactive protein, had no statically significant differences in malaria patients and ABO blood types (Table 2).
Total leukocyte count
was found significantly elevated in diseased group as compared with control group.
The average leukocyte count
is 15,000/[mm.sup.3] and 90% of patients have counts over 10,000/[mm.sup.3].