Leukoplakia


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Related to Leukoplakia: leukoplakia vulvae

leukoplakia

[‚lü·kō′plā·kē·ə]
(medicine)
Formation of thickened white patches on mucous membranes, particularly of the mouth and vulva.

Leukoplakia

 

milky-white spots (radius, to 0.5 cm) on the mucous membranes near the skin (for example, on the lower lip) and on the cheeks, tongue, bottom of the mouth, esophagus, cervix uteri, vagina, and urinary bladder.

Leukoplakia is one of the precancerous diseases. Smoking, advanced tooth decay, excessive consumption of alcohol or spices, certain inflammations of the oral cavity, avitaminosis A or B complex, and poorly fitting metal dental bridges, fillings, and crowns may give rise to leukoplakia. The disease occurs in two forms. In simple leukoplakia, the mucous membrane is smooth; its surface resembles mosaic or parquetry. This may be complicated by fissures or erosions. In verrucose leukoplakia, the mucosa is raised and the color varies from pearly to chalky. Patients complain of sensations of petrifaction, burning, and tenderness. Treatment is by surgical removal, electrocoagulation, or radiation therapy.

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References in periodicals archive ?
Even though leukoplakia doesn't cause discomfort, see your doctor or dentist for a diagnosis.
Proliferative verrucous leukoplakia is a distinct precursor lesion of unknown etiology with a multifocal presentation and a progressive course associated with high recurrence rates and malignant transformation in up to 70% of cases.
Clinico-pathologic evaluation and medical treatment of oral leukoplakia. Inter J Pharma Sci Innver 2014;3:7-14.
(7.) Isenberg, Jason S, MD, PhD;Crozier, Daniel L, MD;Dailey, Seth H, MD Institutional and Comprehensive Review of Laryngeal Leukoplakia. Ann Otol Rhinol Laryngol 2008; 117: 74-9.
Moderately differentiated 71 50.71 squamous cell carcinoma Adenocarcinoma 2 1.43 Invasive carcinoma 2 1.43 Olfactory Neuroblastoma 2 1.43 Adenocystic carcinoma 1 0.71 Verrucous carcinoma 1 0.71 Keratinising squamous 1 0.71 cell carcinoma Premalignant Leukoplakia 9 6.43 Dysplasia 2 1.43 Erythroplakia 1 0.71 Hyperplastic epithelium 1 0.71 Benign Angiofibroma 2 1.43 Spindle cell tumours 2 1.43 Papilloma 2 1.43 Cavernous haemangioma 1 0.71 Capillary haemangioma 1 0.71 Haemangioendothelioma 1 0.71 Pleomorphic adenoma 1 0.71 Leiomyoma 1 0.71 Table 3.
Leukoplakia (homogeneous)###Tobacco/alcohol###Flat white plaque###Low (<5%)
analyzed the apoptotic cells in the saliva of patients with precancerous lesions (OLP, leukoplakia, and oral submucosal fibrosis) and OSCC and found a significantly lower number of salivary apoptotic cells in OSSC compared to that in precancerous lesions [35].
Leukoplakia describes the whitish appearance of squamous epithelium after metaplastic keratinisation has occurred.
OLP can present as painless white streaks, raised, lacy-like lesions, or painful and persistent ulcers or plaques or papules and can resemble leukoplakia [2, 3].
Clinically, intraoral potentially malignant disorders (IOPMD), such as leukoplakia (LKP), erythroplakia (EP), or mixed red and white lesions (erythroleukoplakia (ELKP) or speckled LKP), may precede the OSCC [5].
The most frequent premalignant lesions which can progress to OSCC are oral leukoplakia (OLK), oral lichen planus (OLP), and erythroplasia [5, 9].