Leukoplakia


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Related to Leukoplakia: leukoplakia vulvae

leukoplakia

[‚lü·kō′plā·kē·ə]
(medicine)
Formation of thickened white patches on mucous membranes, particularly of the mouth and vulva.

Leukoplakia

 

milky-white spots (radius, to 0.5 cm) on the mucous membranes near the skin (for example, on the lower lip) and on the cheeks, tongue, bottom of the mouth, esophagus, cervix uteri, vagina, and urinary bladder.

Leukoplakia is one of the precancerous diseases. Smoking, advanced tooth decay, excessive consumption of alcohol or spices, certain inflammations of the oral cavity, avitaminosis A or B complex, and poorly fitting metal dental bridges, fillings, and crowns may give rise to leukoplakia. The disease occurs in two forms. In simple leukoplakia, the mucous membrane is smooth; its surface resembles mosaic or parquetry. This may be complicated by fissures or erosions. In verrucose leukoplakia, the mucosa is raised and the color varies from pearly to chalky. Patients complain of sensations of petrifaction, burning, and tenderness. Treatment is by surgical removal, electrocoagulation, or radiation therapy.

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12,13,16) Men older than 50 years of age were more closely associated with squamous cell carcinoma when leukoplakia was used as a reference group, reinforcing associations observed in previous studies.
Mutated and wild type P53 expression and HPV integration in Proliferative Verrucous Leukoplakia and Oral Squamous Cell Carcinoma.
29) While 85% knew the correct examination of the tongue, only 18% correctly identified erythroplakia as first and leukoplakia as second as the 2 most likely conditions closely related to oral cancer.
Of critical significance is the need to understand and control precancerous lesions, primarily leukoplakia, which when treated may prevent some OPCs from occurring.
The condition occurs in just under three per cent of people and most patients with leukoplakia - about 80 per cent - are over 40.
Most commonly found lesions were oral candidiasis in various forms (3,7,14,18), gingivitis (2,13,14,16), acute her petic gingivostomatitis (2), linear gingival erythema (1,10,17), oral hairy leukoplakia (5,9,13), Kaposi's sarcoma (1,5,15) and parotid enlargement (4,13,15,19).
Oral leukoplakia is the most common premalignant lesion in oral cavity and is associated with the development of oral cancer.
Study Group I included individuals diagnosed with OPMDs such as leukoplakia, OSMF, and erosive lichen planus.
5% (31/40), leukoplakia in 10% (4/40), actinic (lip) keratosis in 10% (4/40) and erythroplakia in 2.
Among 4 cases of leukoplakia, 1 had abusive history of smoking, alcohol and gutka chewing and 3 had history of betel nuts and pan chewing.
Esophageal leukoplakia has a complete basement membrane and does not infiltrate the lamina propria, which is the most important feature for identification of SCC.
Increased number of dental students identified erythroplakia and leukoplakia as oral changes.