(LPG), the major identified ligand from these parasites, has been reported to induce inflammation through TLR2 and 4.
A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan
," Journal of Experimental Medicine, vol.
Leishmania produces a range of glycoconjugates containing phosphoglycan (PG) and two of the most studied abundant surface constituents are the GPI-anchored molecules lipophosphoglycan
(LPG) and GP63 zinc metalloprotease (4) that play important roles in parasite survival and pathogenecity (5).
Leishmania major survival in selective Phlebotomus papatasi sandfly vector requires a specific SCG-encoded lipophosphoglycan
The Leishmania donovani lipophosphoglycan
T lymphocyte reactive component is a tightly associated protein complex.
Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan
Epitope mapping of monoclonal antibodies directed against lipophosphoglycan
of Leishmania major promastigotes.
Leishmania tropica: intraspecific polymorphisms in lipophosphoglycan
correlate with transmission by different Phlebotomus species.