nodule

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Related to Lisch nodules: Neurofibromatosis Type 1

nodule:

see concretionconcretion,
mass or nodule of mineral matter, usually oval or nearly spherical in shape, and occurring in sedimentary rock. It is formed by the accumulation of mineral matter in the pore spaces of the sediment, usually around a fossil or fossil fragment acting as a nucleus.
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nodule

[′näj·ül]
(anatomy)
A small node.
A small aggregation of cells.
(botany)
A bulbous enlargement found on roots of legumes and certain other plants, whose formation is stimulated by symbiotic, nitrogen-fixing bacteria that colonize the roots.
(geology)
A small, hard mass or lump of a mineral or mineral aggregate characterized by a contrasting composition from and a greater hardness than the surrounding sediment or rock matrix in which it is embedded.
(medicine)
A primary skin lesion, seen as a circumscribed solid elevation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

nodule

1. any of the knoblike outgrowths on the roots of clover and many other legumes: contain bacteria involved in nitrogen fixation
2. Anatomy any small node or knoblike protuberance
3. a small rounded lump of rock or mineral substance, esp in a matrix of different rock material
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
Darling, "Multiple, Unilateral Lisch Nodules in the Absence of Other Manifestations of Neurofibromatosis Type 1," Case Reports in Ophthalmological Medicine, vol.
Lisch nodules (Pigmented iris hamartomas) appear as dome-shaped lesions found superficially around the iris on slit-lamp examination.
Caption: Figure 2: (a) Microsection showing bundles of wavy spindle cells with serpentine nuclei in fascicles (H&E, x10x), (b) Strong S-100 positivity of tumor cells (x40x), (c) cafe au lait macule (arrow) in the back, (d) axillary freckle, (e) Lisch nodule (arrow) in slit lamp examination, and (f) father of patient with multiple cutaneous neurofibromas.
Lisch nodules will appear gradually after that, followed by neurofibromas as a sign that the child is entering puberty."
1) six or more cafe-au-lait maculae greater than 5mm(prepubertal) or greater than 15mm (post-pubertal); 2) two or more neurofibromas of any type or one plexiform; 3) freckling in the axillary or inguinal regions; 4) optic glioma; 5) two or more Lisch nodules; 6) distinctive osseous lesion typical of NF 1 e.g.
But patients with Legius syndrome do not develop any other characteristic findings of NF1, such as bone lesions, plexiform or cutaneous neurofibromas, Lisch nodules in the iris, and nervous system tumors.
During follow-up, the patient exhibited no other signs of head and neck neurofibromatosis, and an ophthalmologic examination detected no Lisch nodules in the iris.
The diagnostic criteria typically include two or more of the following: six or more cafe-au-lait spots, two or more neurofibromas or at least one plexiform fibroma, freckling in the axilla or inguinal region, a tumor of the optic pathway, two or more Lisch nodules, a distinctive osseous lesion, or a first-degree relative with neurofibromatosis type 1.
Neurofibromatosis type 1 is the most common of these disorders (affecting 1:3500 individuals worldwide) characterized by cafACopyright-au-late macules, axillary freckling, multiple neurofibromas, Lisch nodules, and bone abnormalities.1,2
* Other less common clinical features of NF1 include plexiform neurofibroma, skeletal abnormalities (short stature, scoliosis, long bone dysplasia, and osteopenia/ osteoporosis), Lisch nodules (iris hamartomas), neurocognitive deficits, cardiovascular abnormalities, and optic pathway gliomas.
According to the 1988 National Institutes of Health Consensus Development Conference, a diagnosis of NF1 requires two or more of the following clinical features: six or more cafeau-lait macules, two or more neurofibromas or one or more plexiform neurofibromas, freckling in the axilla and inguinal region (Crowe's sign), tumor of the optic nerve pathway, two or more Lisch nodules (iris hamartomas), and distinctive osseous lesions.
CLEVELAND -- Both parents of an infant with cafe au lait spots should undergo an expert ophthalmic examination with a slit lamp to see if Lisch nodules are present, Dr.