Los Mochis (lōs mō`chēs), city (1990 pop. 162,659), Sinaloa state, W Mexico. Los Mochis is connected to Mexico City by highway and to the port of Topolobampo by road and rail. It also has an airport. It is the commercial and processing center of the rich agricultural district irrigated by the Fuerte River. Products include grains, sugarcane, and tomatoes as well as cattle and pigs. Los Mochis is additionally a tourist center.