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Related to Lymphocytes: Monocytes, Neutrophils



a variety of white blood cells (agranular leukocytes) in vertebrates and man.

Lymphocytes are spherical in shape and contain an oval nucleus, surrounded by ribosome-rich cytoplasm. Lymphocytes are distinguished, by size, as small (diameter, 4.5–6.5 microns [μ]), large (10–18 μ), and medium (6.5–10 μ). Cells of the small type constitute 95 percent of the total number of lymphocytes. Unlike lymphocytes of the large and medium types, these are incapable of mitosis. However, under the influence of phytohemagglutinin, they turn into large and medium lymphocytes, enter the mitotic cycle, and divide (this method is used in medical genetics for analyzing the cells’ chromosome apparatus). The majority of small lymphocytes are long-lived (in cases, surviving the life of the individual), circulating repeatedly between the lymph and the blood. The short-lived forms survive three to six days.

In mammals and man, lymphocytes are formed in the thymus gland, lymph nodes, spleen, bone marrow (short-lived only), and lymphoid-tissue aggregates (mainly along the digestive tract). The original form from which the lymphocytes of adult mammals develop is the hematopoietic stem cell, the daughter cells of which at first multiply in the thymus and then settle and multiply in the lymph nodes.

The principal functions of the lymphocytes are hematopoietic (certain lymphocytes presumably being capable of differentiation into other blood and connective-tissue cells), trophocytic (possibly serving as suppliers of nutrients and building materials to other cells), and immunological.

The destruction of lymphocytes (by ionizing radiation, antilymphocytic serum, immunodepressant medications) suppresses the body’s immunological reactivity. Advantage is taken of this in cases of tissue and organ transplant (to prevent rejection) and in the treatment of a number of diseases.


References in periodicals archive ?
Flat-walled venules in non-lymphoid tissues including the skin also support leukocyte extravasation under physiological conditions, but unlike HEVs, they allow mainly memory-type lymphocytes and dendritic cells (DCs) to extravasate, (1-3) and the extent of extravasation is much smaller than that observed with HEVs.
Results: A significant difference in the lymphocyte count, ESR, and NLR values was observed among the three groups (P=0.
The basis of rejection or tolerance in organ transplant recipient is the activity of lymphocytes, different subsets of which play different roles in rejection and tolerance.
In this study, Kwon et al found that lymphocyte count was associated with Gleason score upgrading and neutrophil count was associated with biochemical failure; NLR was not found to have association with any of the study endpoints.
Peripheral blood lymphocytes were isolated by the method of zonal centrifugation on a density gradient (3000 rpm/min, K-24) ficollverografine ([rho]=1.
Positive predictive values for C-reactive protein, neutrophil-lymphocyte ratio and platelet- lymphocyte ratio were determined as 82% (odds ratio: 27.
The level of CD4+T lymphocytes were examined among the various study subjects when the OIs were manifested.
Table 1: Frequency of High Neutrophil to Lymphocytes Ration in Patients with non ST Segment Elevation Myocardial Infarction
Yeo, PhD, assistant professor in the Department of Cellular and Molecular Medicine and Institute for Genomic Medicine, said that researchers have been trying for a very long time to understand when and how T lymphocytes give rise to effector and memory cells during an infection.
Receiving the alarm, lymphocytes recognize the menace and call in a range of other cells that actually kill the invaders.
After incubation, the slides were quickly rinsed with SA solution, after which haemo- lymphocytes adhering to the glass slide were fixed by immersing the slide(s) in methanol for at least 5 minutes and thereafter stained with Wright-Giemsa stain.

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