The intestinal glands were greatly developed in the ileum, lymphoid nodules
were observed in the mucosa, and diffuse lymphoid tissue was distributed in the lamina propria.
The central zone (breeding center) of lymphoid nodules
is characterized by an increased content of undifferentiated cells (blasts and large lymphocytes), which can be regarded as a compensatory response to a decrease in their number in the overlying parts of the lymphoid nodules
(I) Lymphatic nodule (a) and diffuse lymphoid nodule
(b) of corpus abomasi.
Photomicrograph of proximal colon in 6 month old buffalo calf showing lymphoglandular complex (LGC) with their mucosal openings (arrows), various lymphoid nodules
(LN) in submucosa (Haematoxylin and Eosin x 20).
On histopathologic examination, the liver, pancreas, and spleen had mild-to-moderate infiltration of lymphocytes some of which were forming lymphoid nodules
An analysis of clinical characteristics of these cases reveals that lymphoid nodules
in the bone marrow in idiopathic myelofibrosis correlates with less-advanced disease, with smaller spleen size and lower WBC and platelet counts.
M cells are specialized epithelial cells of the mucosa-associated lymphoid tissues (MALT), initially identified by electron microscopy in the rabbit appendix and human aggregated lymphoid nodules
(Peyer's patches--PP) (Bockman & Cooper, 1973; Owen & Jones, 1974).
Gastric Marginal Zone (MALT) Lymphoma: Posttherapy Grading (a) Score Lymphoid Infiltrate LELs Stromal Changes CR Absent or scattered plasma - Normal or empty LP cells and small lymphoid and/or fibrosis cells in the LP pMRD Aggregates of lymphoid - Empty LP and/or fibrosis cells or lymphoid nodules
in the LP/muscularis mucosa and/or submucosa rRD Dense, diffuse, or nodular +/- Focal empty LP and/or extending around fibrosis glands in the LP NC Dense, diffuse, or nodular +/- No changes Abbreviations: CR, complete histologic remission; LELs, lymphoepithelial lesions; LP, lamina propria; MALT, mucosa-associated lymphoid tissue; NC, no change; pMRD, probable minimal residual disease; rRD, responding residual disease; -, absent; +/-, present or absent.
In this phase, the lumen of the intestine is obstructed by stool or inflamed submucosal lymphoid nodules
. Pressure builds within the appendix, leading to distention and tire sensation of cramping periumbilical pain.
Melanosis coli characteristically involves all parts of the colon and rectum but tends to spare the regions of mucosa occupied by lymphoid nodules
, polyps, and carcinomas. It has been recommended that during investigation of patients with melanosis coli for suspected mucosal lesions, biopsies should be taken of isolated areas lacking pigmentation if neoplasia is suspected. A possible explanation for the lack of published reports of melanosis coli in patients with Rett syndrome is that although Rett syndrome causes constipation, endoscopic examination of patients is probably unusual.
Furthermore, one should look for destructive cholangitis associated with primary biliary cirrhosis or interface hepatitis (piecemeal necrosis) around lymphoid nodules
with varying degrees of portal fibrosis in cases of chronic hepatitis B or C infection.