In mucosa, glands abnormally develop into tubular and branched tubular glands that are connected by dense connective tissue, and the lymphoid nodule
or tissue mainly exists in the lamina propria (Fig.
Photomicrograph of proximal colon in 6 month old buffalo calf showing lymphoglandular complex (LGC) with their mucosal openings (arrows), various lymphoid nodules
(LN) in submucosa (Haematoxylin and Eosin x 20).
If we consider the changes in the cellular composition of lymphoid nodules
in the whole in animals of one age group (2-3 yrs), it turns out that in case of helminthic infestation the number of stromal cells increased by 2 times.
An analysis of clinical characteristics of these cases reveals that lymphoid nodules
in the bone marrow in idiopathic myelofibrosis correlates with less-advanced disease, with smaller spleen size and lower WBC and platelet counts.
M cells were previously found on the FAE overlying the dome structure of aggregated lymphoid nodules
in the small intestine of humans, as well as in the colon and rectum of mouse (Miller et al., 2007), and they have been identified in a 17-week-old human fetus, the bursa of Fabricius of 15-day-old chick embryos, the ileum of a 7-month-old bovine fetus, and in rats, mice and rabbits (Davis & Owen, 1997).
Structures similar to lymphoid nodules
(Peyer's patches) were also observed in the stomach muscularis.
Melanosis coli characteristically involves all parts of the colon and rectum but tends to spare the regions of mucosa occupied by lymphoid nodules
, polyps, and carcinomas. It has been recommended that during investigation of patients with melanosis coli for suspected mucosal lesions, biopsies should be taken of isolated areas lacking pigmentation if neoplasia is suspected. A possible explanation for the lack of published reports of melanosis coli in patients with Rett syndrome is that although Rett syndrome causes constipation, endoscopic examination of patients is probably unusual.
Comparing with isolate lymphoid nodules
, the difference in dense lymphoid tissue was except no germinal centers, the distribution of reticular fibers was also different.
Furthermore, one should look for destructive cholangitis associated with primary biliary cirrhosis or interface hepatitis (piecemeal necrosis) around lymphoid nodules
with varying degrees of portal fibrosis in cases of chronic hepatitis B or C infection.
Role of Helicobacter pylori in the pathogenesis of gastric carcinoma and progression of lymphoid nodules
All 3 biopsy specimens showed homogeneous eosinophilic material with scattered dense, periductal, and perilobular lymphoid nodules
, similar to the previous biopsy specimens, except for the focal confluent areas.