lymphokine-activated killer cell

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Related to Lymphokine-activated killer cells: LAK cells, Natural killer cells

lymphokine-activated killer cell

[¦lim·fə‚kīn ¦ak·tə‚vād·əd ′kil·ər ‚sel]
(immunology)
A cytotoxic cell that is able to lyse certain cell lines resistant to natural killer cells.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer.
IL-2, which typically binds to the type I cytokine receptors [43], has the ability to activate a population of lymphocytes into lymphokine-activated killer cells (LAK) [47].
Interleukin-12 (IL-12) is an immuno-regulatory cytokine [1] that can activate NK cells, generate lymphokine-activated killer cells (LAKs), and induce interferon-[gamma] (IFN-[gamma]) production and T-cell proliferation [2].