Celgene's lead CAR T trial, TRANSCEND NHL-001, is studying liso-cel in adult patients with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular
lymphoma Grade 3B and mantle cell lymphoma.
The main histological subtypes of non-Hodgkin's lymphoma are the diffuse large B-cell lymphoma, follicular
lymphoma, and Burkitt lymphoma [9-11].
(3) The majority of PBL are diffuse large B-cell lymphomas (DLBCL), but other less frequent subtypes including mucosal-associated lymphoid tissue lymphoma, follicular
lymphoma, Burkitt lymphoma and T-cell lymphoma.
The study will primarily enrol CLL patients but smaller cohorts of patients with other types of NHL, such as mantle cell lymphoma, follicular
lymphoma and diffuse large B-cell lymphoma, may also be recruited.
This may be most commonly seen in the nonblastic B-cell lymphomas (small lymphocytic lymphoma/chronic lymphocytic leukemia, marginal zone lymphoma, follicular
lymphoma, and mantle cell lymphoma).
The most common histological finding in prostatic lymphoma is Diffuse large B-cell lymphoma, but primary prostatic small lymphocytic lymphoma, follicular
lymphomas, Burkit lymphomas, MALT lymphomas, and mantle cell lymphomas have also been reported.