In immunohistochemistry testing using the unconjugated antibody component of STRO-001 with a large number of human lymphoma tissue samples, researchers also confirmed that CD74 is highly-expressed in diffuse large B-cell lymphoma, follicular
lymphoma, and mantle cell lymphoma.
3) The majority of PBL are diffuse large B-cell lymphomas (DLBCL), but other less frequent subtypes including mucosal-associated lymphoid tissue lymphoma, follicular
lymphoma, Burkitt lymphoma and T-cell lymphoma.
The study will primarily enrol CLL patients but smaller cohorts of patients with other types of NHL, such as mantle cell lymphoma, follicular
lymphoma and diffuse large B-cell lymphoma, may also be recruited.
This may be most commonly seen in the nonblastic B-cell lymphomas (small lymphocytic lymphoma/chronic lymphocytic leukemia, marginal zone lymphoma, follicular
lymphoma, and mantle cell lymphoma).