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(chemical engineering)
Rapid freezing of a material, especially biological specimens for preservation, at a very low temperature followed by rapid dehydration by sublimation in a high vacuum.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



freeze-drying, the drying of biological objects in a frozen state under vacuum, the water being removed by sublimation of the ice (that is, conversion to steam, bypassing the liquid phase).

Lyophilization makes it possible to obtain dry tissues, medical preparations, and food products without a loss of structural integrity and biological activity. Most proteins are not denatured by the process and can be stored for a long time afterward under moderate cold (about 0°C). Freeze-dried tissues and preparations regain their initial properties when wetted. The process is used when there is a need for the long-term storage and preservation of various products of biological origin; to obtain dry donor plasma and dry sera and vaccines; for organ and tissue transplants; and in the pharmaceuticals and food industries. In the life-support systems of spaceships, it may be used as a means of regenerating water from moisture-containing materials.


Primenenie zamorazhivaniia-vysushivaniia ν biologii. Edited by R. Harris. Moscow, 1956. (Translated from English.)
The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
In the run up to the conference, the SMi Group caught up with Lauren Fontana from Sanofi R&D who will be presenting on Day One, to discuss her upcoming presentation and her thoughts on the current challenges and opportunities in Lyophilization.
The facility includes four high speed, automated aseptic fill lines and commercial scale lyophilization for the manufacture of clinical and commercial drug products.
For more information on lyophilization developments, click on the blue-colored headlines at this link.
Founded in 1997, LSNE is a market leader providing a wide range of development and manufacturing services to the pharmaceutical, biotechnology and medical device industries, specializing in aseptic fill/finish and lyophilization services.
The product obtained from the lyophilization was transferred to a plastic package, which was sealed and manually compressed in order to the powder product.
This report provides both, qualitative and quantitative analyses of the market for lyophilization equipment.
The average moisture contents of the jaboticaba skin flour obtained from the treatments at 30, 45 and 60[degrees]C and by lyophilization were 10.36 [+ or -] 0.50, 1.66 [+ or -] 0.36, 0,38 [+ or -] 0.22 and 9.30 [+ or -] 0.39, respectively.
Cryopreservation in liquid nitrogen and lyophilization are recommended and used by the American Type Culture Collection [12].
To overcome this issue, Actelion Pharmaceuticals adopted the fast lyophilization (LyoSpeed) methodology developed by Genevac, and implemented this using the Genevac HT-12 centrifugal evaporation systems.
Therefore, the extra steps of previous lyophilization and PVP addition during the maceration might ensure efficiency and reliability, improving the amount of DNA purified as well as reducing problems with the co-isolation of undesirable constituents, such as polysaccharides and polyphenols.
Many biotechnology products require lyophilization, a process of freeze-drying sterile solutions to permit a shelf stable dosage form.
tissue bank to import a new freeze-drying method of preserving donated tissue known as lyophilization.