Lysolecithin


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Lysolecithin

 

(l-acylglycero-3-phosphorylcholine), the product of the removal of a single fatty acid molecule from lecithin; a phospholipid fraction.

Small quantities of lysolecithin are found in many animal and plant tissues. The richest sources are blood and the adrenal glands. Lysolecithin forms in the organism from lecithin under the influence of the enzyme phospholipase. It alters the permeability of biological membranes, induces the hemolysis of erythrocytes, regulates the permeability of vascular walls, and reduces cardiac sensitivity to acetylcholine. In the organism, lysolecithin is found in the form of a compound with albumin and cholesterol. (The latter reduces lysolecithin’s biological activity.)

References in periodicals archive ?
Interaction between fat type and lysolecithin supplementation in broiler feeds.
SCI animal model Primary Motor neuron pathology Traumatic lesion Contrusion Spinal cord Axonal Compression disruption atrophy Traction Laceration Sugical incision Transection Dorsal hemisection Lateral hemisection Ischemic lesion Vascular congestion Aortic occlusion Quisqualic acid Cytotoxicity Reduced Glutamate Drugs N-Methylasparate Kainic acid Cuprizone Partial Lysolecithin demyelination TME Virus Axonal Virus infection MH Virus Demyelination atrophy
(9) The enzyme attacked only lysolecithin but not lecithin.
Moreover, during absorption from the intestine, vitamin A and [beta]-carotene become finely dispersed in the intestinal fluid in mixed lipid micelles formed with the aid of bile salts, lysolecithin, lower glycerides, and cholesterol.
ALB, an abundant serum protein of MW of ~66 KDa, binds and transports a variety of ligands such as steroids, fatty acids, bilirubin, lysolecithin, prostaglandins, thyroid hormones, and drugs.
The conversion of lecithin to lysolecithin (a toxic compound) by phospholipase A2 can lead to cell injury, while lipolysis can disrupt the structure and integrity of gastric mucus.10
In the weeks after radiation, the researchers injected the mice with lysolecithin, a substance that caused brain damage by inducing a demyelinating brain lesion, much like that present in MS.
Lp(a) also contains lipoprotein-associated phospholipase [A.sub.2] (Lp-[PLA.sub.2]) which may cleave oxidized fatty acids to yield short-chain fatty acids and lysolecithin (12).
Effect of apoprotein B conformation on the activation of lysolecithin acyltransferase and lecithin: cholesterol acyltransferase.
Hyphema may be due to the haemolytic effect of phospholipase A and lysolecithin. Hyaluronidase, hemolitin, minimine and other amines of the venom may cause degeneration and lysis of the chromophores leading to iris despigmentation (4).
Impairment of endothelial-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins.
Lecithin and/or lysolecithin is added to an animal feed including an exogenous enzyme to boost the performance of the enzyme so that a desired level of performance can be maintained while reducing the amount of exogenous enzyme that must be included in the animal feed.