The differentiation between latent and lytic infection rely on identification of the viral genome (DNA) and viral transcripts (mRNA) for one of the structural genes.
Since EHV-1 is a DNA virus, this type of PCR is rarely used to detect lytic infections but more likely for detecting and quantifying latent EHV-1 in tissues and whole blood (Borchers et al., 1999; Chesters et al., 1997).
In a lytic infection the virus is exposed to components of the immune response that have the potential to clear the virus from the host.
Latency can be thought of as an extension of a lytic infection or perhaps as a diversion from it.
During latency the virus DNA is present in the neuron cell nucleus, but it has no way to be replicated or to create a lytic infection. Reactivation follows after a stimulus that is not well characterized [14,15].
Evidence of lytic infection
of Epstein-Barr virus (EBV) in EBV-positive gastric carcinoma.
PML, caused by the John Cunningham (JC) virus, results from lytic infection
of predominantly astroglial cells.
pylori associated NH2Cl induces EBV lytic infection
from latent infection in gastric epithelium latently infected with EBV.
Acute disease manifests itself as a lytic infection
of rapidly dividing cells; chronic disease reflects a restricted or abortive infection of specific cell types (1).
After the virus enters the host, IBDV causes acute lytic infections
and high titers of anti-IBDV antibodies [5, 14].