monoclonal antibody

(redirected from Mab)
Also found in: Dictionary, Thesaurus, Medical, Financial, Acronyms, Wikipedia.

monoclonal antibody,

an antibody that is mass produced in the laboratory from a single clone and that recognizes only one antigen. Monoclonal antibodies are typically made by fusing a normally short-lived, antibody-producing B cell (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
..... Click the link for more information.
) to a fast-growing cell, such as a cancer cell (sometimes referred to as an "immortal" cell). The resulting hybrid cell, or hybridoma, multiplies rapidly, creating a clone that produces large quantities of the antibody.

Monoclonal antibodies engendered much excitement in the medical world and in the financial world in the 1980s, especially as potential cures for cancer. They have been used in laboratory research and in medical tests since the mid-1970s, but their effectiveness in disease treatment was limited especially by the tendency of the early monoclonal antibodies to provoke an immune response against them because of the use of mouse cells in creating the hybridoma. This problem has been overcome through the use of recombinant DNA to produce chimeric and humanized monoclonal antibodies and of transgenic mice and other techniques to produce human antibodies. Monoclonal antibody therapies have been developed to treat transplant rejection, some autoimmune diseases, and some types of lymphoma, leukemia, and breast and other cancers. These therapies use monoclonal antibodies to home in on specific antigens found on the surface of targeted cells to deliver radioactive materials, drugs or inactive drug precursors (subsequent converted to a drug by an enzyme), tumor-suppressing genes, or substances that suppress or inhibit signaling molecules involved in disease processes.


See study by L. V. Marks (2015).

monoclonal antibody

[¦män·ə¦klō·nəl ′ant·i‚bäd·ē]
A highly specific antibody produced by hybridoma cells; the antibody binds with a single antigenic determinant.

monoclonal antibody

an antibody, produced by a single clone of cells grown in culture, that is both pure and specific and is capable of proliferating indefinitely to produce unlimited quantities of identical antibodies: used in diagnosis, therapy, and biotechnology
References in periodicals archive ?
Like many leading FM companies, MAB has witnessed its share of contract regains in recent times.
Sector: el MAB se centra en empresas de los sectores servicio, comercio y manufactura.
Anti-ferritin mAb 2F9-C9 was purified from culture supernatants by affinity chromatography using a Hi-Trap protein G column (GE Healthcare, Uppsala, Sweden).
22) Such kind of increasing patient population with considerable consumption capability provides unique opportunities for Mab products.
El mismo MAB supo que ahi habia encontrado algo, que esa imagen es uno de los momentos culminantes de su vida.
Desde que Shakespeare la introduce en su teatro, el hada Mab aparece en numerosas obras (9) como la figura mitica cuyos poderes--hacer que las personas tengan visiones oniricas de sus mas anhelados deseos--sirven al artista para conferir un ambiente magico a la obra, o cierto dramatismo a una escena o a un personaje (Shakespeare) o para transmitir un mensaje moral o filosofico (Shelley).
ZymoGenetics also has a right to co-promote the IL-21 mAb product in the US if the company contributes to Phase III clinical development costs.
Led by Allen Featherstone, Professor of agriculture economics, the first MAB class was made up of students mostly from the Great Plains, but as the program has grown and diversified, so have the students.
Kirin believes CD40 antagonistic mAb contributes to medication for transplantation and autoimmune diseases.
We also found that assays using mAb A11 and any one of mAbs A8, A9, and A16 were able to detect recombinant proMBP (Fig.
Los Angeles-area researchers are evaluating OvaRex MAb, an antibody that targets a marker found in the blood associated with ovarian cancer.
MAB owns wine bar chains All Bar One and Browns, and Harvester and Toby Carvery restaurants.