To summarize, resveratrol, quercetin, pterostilbene, and caffeic acid actually impaired the detection of the produced hydrogen peroxide without preventing benzylamine degradation and behaved as MAO inhibitors
and SSAO inhibitors only in appearance, as schematized in Figure 7.
A few irreversible or non-selective MAO inhibitors
It is probable that one of the leading causes of protracted depressive states may be an autoimmune process, and specifically, the formation of auto-antibodies to the endogenous MAO inhibitor
isatin or isatin containing tribuline.
like Parnate block the enzyme monoarnine oxidase, which breaks down serotonin and norepinephrine.
more than 150 mg) of tyramine by patients taking MAO inhibitors
, including Azilect([R]), should be avoided.
At a meeting, the FDA's Psychopharmacologic Drugs Advisory Committee voted 7-4 that the available data supported the "reasonable safety" of the 20-mg formulation of a transdermal patch containing the irreversible MAO inhibitor
selegiline without a recommendation to restrict aged cheeses and other tyramine-rich foods in the diet.
The approval marks another first: The lowest dose--the 20-mg patch that delivers 6 mg of selegiline over 24 hours--does not require dietary tyramine restrictions, making this the first MAO inhibitor
approved for treating depression without such a restriction.
1% of all antidepressant prescriptions were for an MAO inhibitor
, according to data from IMS provided by Somerset at the meeting.
Conventional MAO inhibitors
interfere with the action of an isoenzyme, MAO-A, that normally prevents the absorption of tyramine, a food component that can raise blood pressure dramatically, he said.
Zinx[TM] Chlor-D and Zinx[TM] PCM are also contraindicated in patients with severe hypertension, severe coronary artery disease, patients on MAO inhibitor
therapy, patients with narrow angle glaucoma and/or peptic ulcer.
The most treatment-refractory patients may respond to a tricyclic, possibly in combination with an SSRI, or to an MAO inhibitor
Cigarette smoke inhibits MAO activity, possibly through components other than nicotine, and the selective MAO inhibitor
selegiline reduced craving and smoking in a lab study.