While p38 MAPKs
are proline-directed kinases, substrate specificity is also determined by docking domains both in the MAPK
itself and in the target protein .
The activation of the p38 MAPK
signaling pathway in myocardial tissues was determined using RT-PCR and Western blotting.
In addition to the Phase 2b monotherapy trial in NF1-associated PN, and given the critical role that the MAPK
pathway plays in the growth and proliferation of a large number of tumor types, SpringWorks is also pursuing mirdametinib in combination with other rational anti-cancer agents across a range of solid tumors.
Conclusion: These results suggest that puerarin might suppress the PM2.5-induced VSMCs proliferation via the inhibition of the p38 MAPK
The GC-GR complex then migrates to the nucleus, binds to the glucocorticoid response element, and activates the transcription of target genes, including MKP-1 , GILZ , and SGK1 . Via binding to the receptor, GCs are able to inhibit p38 MAPK
by inducing MKP-1, which in turn results in de-phosphorylation of p38. MKP-1 is a phosphatase that dephosphorylates and inactivates MAPKs
, including p38 MAPK
, and inhibits production of pro-inflammatory cytokines, which is critical for the anti-inflammatory functions of GCs. Clark et al . proposed that MKP-1 played a role in the inhibition of p38 MAPK
and the consequent destabilization of pro-inflammatory mRNAs by GCs.
Citation: Takashi Iezaki et al., The MAPK
Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.
GSTD-induced HO-1 and Nrf2 protein expression was involved in protecting [H.sub.2][O.sub.2]-induced oxidative injury in LSECs, which might be a common protective mechanism for liver oxidative detoxification regulated by p p38 MAPK
. GSTD may be a protective agent against hepatic diseases associated with oxidative stress.
Pathway Across Different Malignancies: A new perspective.
cascade was the most significant gene ontology (GO) term from the functional annotation results of significant genes and other GO terms related to MAPK
cascade appeared multiple times as well.
Inhibitory Effects of GA on HL60 Cell Migration Are Mediated through Activation of MAPK
and Activator Protein- (AP-) 1.
Antibodies purchased from Cell Signaling Technology (Danvers, MA, USA) included TNF-[alpha], PPAR[gamma], RXR[alpha], IL-6, IL-1[beta], LC3, NF-[kappa]B p65, P38 MAPK
, p-P38 MAPK
, JNK, p-JNK, ERK, and p-ERK.
Moreover, it has been found that ICA exerts multiple effects on BMSCs by activating MAPK
signal pathway, including its ability to promote the proliferation and osteogenic, chondrogenic, and adipogenic differentiation [17-19].