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Expression levels of MMP1, MMP2, TIMP1, and TIMP2 were measured by quantitative real-time polymerase chain reaction (RT-PCR).
Among the genes of the MMPs family spotted on our array, MMP1, MMP12 (macrophage elastase), MMP14, and MMP-19 had enhanced expression in subjects from the high-level arsenic exposure group.
controls OSCC [up arrow] MMP1, [up arrow] KNG1, [up arrow] ANXA2, and [up arrow] HSPA5 in OSCC patients vs.
In fact, NF[kappa]B-and ERK-pathways are known to be the main mechanisms that induce MMP13 and MMP1 expression in chondrocytes [35-37].
We have previously shown that ROS mediated MMP1 induction in UVB exposed HDFs was accompanied by connective tissue breakdown.
Recently, a naturally occurring sequence variation in the human MMP1 gene promoter was reported (10).
MMP1, a member of the MMP family, can degrade interstitial collagen types I, II, and III, clearing a path for cancer cells to invade matrix barriers and migrate through tissue stroma .
Catechin, the major flavan of Acacia, also inhibited the degradation of human and bovine cartilage proteoglycan and type II collagen  and hindered IL-[beta] induced cartilage proteoglycan degradation and expression of matrix metalloproteinases (MMP1 and MP-13) in human chondrocytes .
Circulating levels of resistin positively correlates with leptin levels and IL-6, MMP1, and MMP3 levels in SF, with no significant difference for diabetic versus non-diabetic patients or gender or hand OA [169, 173].
Here, we demonstrated that ginsenoside Rd inhibited invasion and metastasis by reducing the expression of MMP1, MMP2, and MMP7, by blocking MAPK signaling by inhibiting the phosphorylation of ERIC, JNK, and p38 MAPK, and by inhibiting AP-1 transcriptional activation.
With the method described above, 11 of 36 messages studied were undetectable in either PAXgene or EDTA blood from either donor (ILlA, IL2, IL4, IL6, IL7, IL-12p40, GM-CSF, TNFB, MMP1, MMP2, and CYCLD).
It suppresses lung cancer progression by targeting FOXM1 ; inhibits hepatocellular carcinoma cell growth by targeting CXCR6 ; decreases glycolytic metabolism, proliferation, and invasion of breast cancer by targeting FGFR1 and MMP1 ; and prevents the malignant progression of prostate cancer cells by targeting STAT6 .
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