The effect of
MSTN, FS, and testosterone is not fully known.
Gene expression of atrogin-1, MuRF1, GABARAP, LC3 and cathepsin Lin A, soleus, B, extensor digitorum longus (EDL), and C, C2C12 cells incubated with myostatin (
MSTN) for 4 h.
The myostatin (
MSTN) gene encodes a growth factor, sometimes referred to as growth differentiation factor 8 (GDF-8).
Like other TGF-[beta] superfamily members, activins and
MSTN signal via a heteromeric complex of type II and type I receptors.
In order to detect the digestion pattern of
MSTN gene fragment of 337 BPit was digested with HaeIIIenzyme .
Estudos que demonstraram diminuicao da expressao de
MSTN pelo treinamento resistido de alta intensidade (Roth e Walsh, 2004) e BIOV (Laurentino, 2010) constataram aumentos significativos de AST e forca muscular.
Known as
MSTN, the gene regulates myostatin, a protein that controls muscle cell production.
Myostatin (
MSTN) negatively regulates muscle growth in mammals, with some evidence in support of a similar role in fish.
For knockout of the chicken myostatin (
MSTN) gene, the nickase target loci were designed in exon 1 of chicken
MSTN gene (Figure 1A).
Also, the phosphorylation of Smad2/3 can transduce signals of
MSTN, one of the most powerful inhibitors of muscle growth [33-35].
For example, the 5-bp indel within the 5' UTR of the
MSTN gene altered the functional structure of the
MSTN protein so that the growth traits in goats were affected (Zhang et al., 2012).
We previously performed single-nucleotide polymorphism (SNP) analysis and molecular genetics research on
MSTN, ESR, H-FABP, SLA, DQA, DQB, and PPARr-2 genes.