macromutation

(redirected from Macromutations)
Also found in: Dictionary, Medical.
Related to Macromutations: punctuated equilibrium, macroevolution

macromutation

[‚mak·rə·myü′tā·shən]
(genetics)
Any genetic change that leads to a pronounced phenotypic alteration.
Mentioned in ?
References in periodicals archive ?
Everyone agreed that Darwin's process could explain changes to the left of this point (microevolution), but some now argued that a fundamentally new phenomenon called genetic mutation or macromutation was responsible for the larger-scale differences to the right (macroevolution).
Long jumps, forced macromutations might prove very effective on rugged landscapes, where many fitness peaks exist, though they become a weak strategy as the complexity (diversity and numbers) increases.
Many mechanisms have been proposed to explain these shifts, most prominently Wright's (1977) shifting balance; others have included Fisher's (1958) idea that individual fitnesses change frequently and Goldschmidt's (1940) macromutations.