Macrophages


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Related to Macrophages: Natural killer cells, Dendritic cells

Macrophages

 

polyblasts; mesenchymal animal cells capable of capturing and digesting bacteria, the remains of dead cells, and other foreign or toxic particles (phagocytosis).

The term “macrophage,” which was introduced by E. Metchnikoff in 1892, refers to the monocytes of the blood, the histiocytes of connective tissue, the endothelial cells of the capillaries (sinusoids) of the hematopoietic organs, the Kupfer cells of the liver, the cells of walls of the alveoli of the lungs (pulmonary macrophages), and the cells of the walls of the peritoneum (peritoneal macrophages). It has been established that the precursors of macrophages in mammals are formed in the bone marrow. The cells of the reticular tissue of the hematopoietic organs also exhibit phagocytic properties. Together with macrophages, they make up the reticuloendothelial, or macrophage, system, which has a protective function in the body.

N. G. KHRUSHCHOV

References in periodicals archive ?
peregrina on LPS-induced IL-16 expression in J774A.1 macrophages
IL-1[beta] is a potent activator that may stimulate NO production in macrophages. The activation of macrophages with LPS trigged the expression of proinflammatory cytokines IL-1[beta] in a concentration-dependent manner as shown in Figure 3.
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: Roles in homeostasis and disease.
The metabolic ER stress sensor IRE1a suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
While these anti-inflammatory macrophages had been used in muscle-healing therapies before, they had never been integrated into a platform aimed at growing complex muscle tissues outside of the body.
The typical inflammatory granulomatous response is a tissue chronic reaction that causes targeted lesions as a result of in situ persistence of injury by the pathogen agent, where predominantly the mononuclear phagocytic cells form aggregates of macrophages and multinucleated giant cells, which in most cases are surrounded by lymphocytes, and depending on the time of development, they could display fibrosis (Williams and Williams, 1983; Perez-Torres et al.
Macrophages are specialized cells involved in the detection, phagocytosis and destruction of cancerous cells, bacteria and other harmful organisms.
To confirm the cellular identity of the [iron.sup.+] species and characterize the microenvironment of the iron deposits, Prussian blue iron histochemistry (Figure 2(a)) and immunofluorescence for [F4/80.sup.+] (Figure 2(b)) macrophages and [CD31.sup.+] vasculature (Figure 2(c)) was performed.
Currently, numerous studies have shown that histone methylation modification plays an important role in the polarization of macrophages [15-17].
Macrophages were treated with or without different reagents as indicated for 24 h.
This view has been completely reconsidered over the last decade, and the ontogeny of macrophages has been totally rewritten, based on genetic approaches of cell fate mapping.