Malignant Catarrhal Fever


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Malignant Catarrhal Fever

 

of cattle, an acute viral disease characterized by croupous inflammation of the mucous membranes of the gastrointestinal tract and the respiratory tract and by affection of the eyes and central nervous system.

Under natural conditions, cattle and buffaloes, irrespective of breed, sex, or age, are susceptible. The disease is recorded in the majority of countries; it usually occurs in isolated cases. Malignant catarrhal fever is most often observed in spring and autumn. The pathways of natural infection and spread of the disease have not been sufficiently studied. The course is acute, more rarely subacute.

The clinical symptoms are chills, a rise in general temperature (up to 40°C–42°C) and local temperatures (at the base of the horns), increased thirst, and decreased appetite. Milk secretion ceases; the coat becomes scruffy, and the skin dry. The lymph nodes become enlarged. Shivering of certain groups of muscles is observed, as are wobbly gait and attacks of restlessness. Photophobia, epiphora, edema of the eyelids, and a purulent discharge from the eyes appear on the second to third day. In complicated cases there are ulcers on the cornea. The inflammatory process gradually embraces the nasal cavity and the frontal and maxillary sinuses; a cough appears, and there is dyspnea and difficulty in swallowing.

The diseased animals perish on the fourth to the tenth day in an acute course, and on the 14th to 20th day in subacute cases. Sick animals are isolated and treated with antibiotics and sulfanilamide preparations or are slaughtered in an abattoir. Use of the slaughtered meat is strictly regulated.

REFERENCE

Epizootologiia. Edited by R. F. Sosov. Moscow, 1969.
References in periodicals archive ?
Number of deer tested for bluetongue (BT), epizootic hemorrhagic disease (EHD), bovine viral diarrhea (BVD) I and II, Johne's disease, West Nile virus (WNV), and malignant catarrhal fever (MCF) at Wind Cave National Park, South Dakota, USA, from 2003 to 2005 with number of deer testing antibody positive shown in parentheses.
An outbreak of porcine malignant catarrhal fever in a farrow-to-finish swine farm in the United States.
PCR detection of the sheep-associated agent of malignant catarrhal fever. Arch Virol.
Chronic generalized obliterative arteriopathy in cattle: a sequel to sheep-associated malignant catarrhal fever. J Vet Diagn Invest.
Recognition of another member of the malignant catarrhal fever virus group: an endemic gammaherpesvirus in domestic goats.
Molecular diagnosis of alcelaphine herpesvirus (malignant catarrhal fever) infections by nested amplification of viral DNA in bovine blood buffy coat specimens.
In a typical ELISA, the malignant catarrhal fever virus is applied to the bottom of a plastic plate.
A problem is that the cow's blood contains many antibodies--not just those generated in response to the malignant catarrhal fever virus.
If the cow's blood doesn't have natural antibodies to malignant catarrhal fever virus, the monoclonal antibody will form a bond to the ELISA plate that is indicated by a color change.

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