malignant

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malignant

1. Pathol (of a tumour) uncontrollable or resistant to therapy; rapidly spreading
2. History (in the English Civil War) a Parliamentarian term for a royalist

malignant

[mə′līg·nənt]
(cell and molecular biology)
Pertaining to cells that have undergone phenotypic transformation by oncogenes or protooncogenes.
(medicine)
Endangering the life or health of an individual.
Of or pertaining to the growth and proliferation of certain neoplasms which terminate in death if not checked by treatment.
References in periodicals archive ?
The greatest variation occurred in images containing higher percentages of malignant cells (>40%).
Once docked, the vehicle unloads its "passenger," the cisplatin, into the malignant cell.
The diagnosis of malignant mesothelioma was supported by the intense reactivity of the malignant cells with cytokeratin, EMA, and calretinin.
While conventional anti-cancer approaches focus on targeting malignant cells for destruction, MEL's method of tumor eradication seeks to "reprogram" cancerous cells towards a non-malignant state.
These data support the concept that short telomeres in malignant cells will render them highly sensitive to telomerase inhibition.
When mixed with cells from human head and neck cancers, curcumin stopped proliferation and induced cell suicide, or apoptosis, in the malignant cells, says study coauthor Yasunari Takada, a molecular biologist at M.
Cytology demonstrated malignant cells consistent with a poorly differentiated epithelial malignancy (figure 2, A); on this basis, melanoma and lymphoma were ruled out.
Decitabine's unique mechanism of action - inhibition of DNA hypermethylation - specifically targets the series of events that lead to the formation of malignant cells.
The SPECIFID panel of 15 antibodies targets cell-surface markers present only on the malignant cells of the tumors of approximately 25 percent of patients with non-Hodgkin's B-cell lymphoma.
Unfortunately, excess heparanase can weaken the membrane and permit metastasis, the spread of malignant cells to other organs.
Analysis of the aspiration smears revealed the presence of malignant cells (figure 3).
Ligand applied to the European Agency for the Evaluation of Medicinal Products (EMEA) via the centralized procedure to market ONZAR for the treatment of persistent or recurrent CTCL in patients whose malignant cells express the p55 (CD25) component of the IL-2 receptor and who have received one or more prior systemic therapies.