Mannose


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mannose

[′ma‚nōs]
(biochemistry)
C6H12O6 A fermentable monosaccharide obtained from manna.

Mannose

 

a monosaccharide of the general formula C6H12O6 (an isomer of glucose); a component of many polysaccharides and mixed biopolymers of plant, animal, and bacterial origin.

Mannose is readily soluble in water and has a sweet taste. Its melting point is 132°C Only the D-form occurs naturally. In its free form, mannose is present in many citrus fruits, as well as in fruits of the genera Anacardium and Corynocarpus. Mannose is converted in the organism with the help of its activated form, guanosine diphosphate mannose (GDPM), which serves as a mannose-radical donor in the synthesis of mannans and other biopolymers.

References in periodicals archive ?
These peaks were compared with standards, which showed three different monosaccharides including maltose, glucose and mannose in hydrolyzed solution of A.
Compared with standard sugar injection, the chromatogram of hydrolyzed MCC EPS showed the retention times of 6.53, 10.23, 11.37, 14.73, 15.90 and 17.23 min; which were the retention times of fucose, rhamnose, arabinose, galactose, glucose and mannose, respectively.
albicans, these mannose residues are also present and are likely to be incorporated to glycans via the same protein [54]; however, it is most frequent that the [alpha]1,2-mannose branches are further decorated and capped with [beta]1,2-mannose units [55].
Group 1 C-Type Lectin Receptors: The Mannose Receptors
The lectins used were: (1) Concanavalin-A (Con-A) to recognize glucose (Glc), (2) Glanthus nivalis (GNL) for mannose ([alpha] 1-3) mannose (Man-Man), (3) Lens culinaris agglutinin (LCA) for [alpha]-mannose (Man) and [alpha]-glucose (Glc), (4) Lotus tetranoglobus agglutinin (LTA) for fucose (Fuc), (5) Badeiraea simplicifolia-I (BS-I) for galactose (Gal), (6) Griffonia simplicifolia (GSL II) for N-acetyl-glucosamine (N-AcGlc), and (7) Dolichos biflorus agglutinin (DBA) for N-acetyl-galactosamine (N-AcGal) at concentrations of 10 mg [mL.sup.-1] each.
Negative control Positive control Mucus Nitzschia 1.0 (0.0) 13.1 (0.5) 6.1 (0.1)* cloterium Rhodomonas 1.0 (0.0) 7.3 (0.1) 4.6 (0.2)* salina Tetraselmis 1.0 (0.0) 7.0 (0.1) 2.4 (0.1)* maculata Mucus + Carbohydrates Species Glucose Mannose Isochrysis 5.3 (0.0)[dagger] 4.7 (0,2)[dagger] sp.
Effect of sugars, chelators, and inhibitors on MBL-MASPs mediated complement assay: Purified MBL-MASPs were incubated with mannan coated RBCs in presence of the sugars and chelators such as mannose (1.5%), glucose (1.5%), Ca[Cl.sub.2] (2 mM), EDTA (10 mM), Mg[Cl.sub.2]-ethylene glycol tetraacetic acid (EGTA) (0.5 and 10 mM respectively) and lytic activity was checked.
Antisense inhibition of the GMPase led to a significant reduction of the mannose content in leaf cell walls, indicaing that GDP-D-mannose is the sole precursor for the incorporation of mannose into hemicellulose (Keller et al.
The present data suggested that lipid vesicle-trapped herbal antioxidant quercetin and CDP-Choline may not only be effective in combating the cerebral ischemic reperfusion oxidative damage but also to prevent cerebral edema development both in young and old animals) The mechanism how quercetin and CDP-Choline in mannosylated liposome exerts a complete protection against ischemia-reperfusion mediated cerebral oxidative damage in young and aged rats is not fully clear) Although expression of the mannose mannosylated liposomes were successfully incorporated into mouse brain)
DAVANAT, the company's lead drug candidate, is a carbohydrate (polysaccharide) polymer derived from plant sources composed of mannose and galactose.
Drawn from the symposium of September 2003 in New York, the general topics of these 23 papers include an overview, advances in polymeric matrices (including injectables, poly(ortho esters) novel nanogels, hydrogels, dual-release minirods, Fourier transform infrared imaging, and silver-based antimicrobal coatings, and drug particle engineering, including using supercritical fluid technology, compressed carbon dioxide, mixing and block copolymer stabilization, spray freezing into a liquid, and fast-dissolving tablets based on mannose.