Mast Cell


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mast cell

[′mast ‚sel]
(histology)
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell

 

(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
Wu, "Molecular regulation of mast cell development and maturation," Molecular Biology Reports, vol.
Antigenically altered basal epithelial cells stimulate the mucosal mast cells through RANTES.
However, mast cell reconstitution did not reduce the elevated IL6 or IL12p40, indicating that mast cells may be specifically regulating specific cytokines and (or) proinflammatory mediators to dampen colitis.
Several studies reported the occurrence of particular tumors in particular breeds such as, mammary tumor in German shepherd and Cocker spaniel (Frye et al., 1967) and mast cell tumors in Labrador and Golden retriever (Mcnielet al., 2004; Murphy et al., 2004).
If there are no improvements in symptom presentation after a patient has been on the diet for a month, the likelihood of a notable mast cell contributor is minimal.
A previous study by Theoharides and colleagues showed that restraint stress alone may cause mast cell degranulation in rat brains through stimulation of the hypothalamic-pituitary-adrenal axis (Theoharides et al., 1995).
It was reported that plasma levels of some mast cell mediators including histamine, triptase, TNF-a and interleukin-1 (IL-1) were increased during migraine attack (18).
Even though, chemotherapy in mast cell tumor had not been well defined, it could be used as an adjunct therapy in high grade tumors and alternativeto radiational therapy for incompletely excised tumors.
The mast cells showed various shapes and sizes in the small intestine and could be detected at four layered structures in the small intestine, but were mainly distributed in the lamina propria and the submucosa, surrounded with connective tissue and blood vessels.
Wechsler seeks to understand the role of esophageal mast cell activation in EoE symptoms, along with endoscopic abnormalities in EoE and the effect of treatment.
"Everybody has mast cells in their body, but my body reproduces more and more rather than just reproducing the ones I need, which then causes me to have an extremely high histamine level in my blood," she said.
"For this reason, we must make sure that our health providers are aware of illnesses such as Mast Cell, so they can provide the same excellent service they do with more recognised illnesses.