Mast Cell

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mast cell

[′mast ‚sel]
A connective-tissue cell with numerous large, basophilic, metachromatic granules in the cytoplasm.

Mast Cell


(also called mastocyte or labrocyte), a reticular connective tissue cell in animals and man. The number of mast cells depends on the species and on the functional state of the connective tissue. The mast cell contains metachromatic cytoplasmic granules; the size and number of granules depend on the species and on the maturity and functional state of the cell. Mast cells contain a number of physiologically active substances, notably heparin, histamine, and serotonin. Consequently, it is believed that the mast cell plays a role in anaphylaxis, inflammation, and blood clotting. Mast cells rarely divide by mitosis. The principles of their origin and reproduction remain obscure.

References in periodicals archive ?
Given individual genetics and chemistry, and the fact that mast cells can produce over 200 different biochemical mediators depending on the stimulus they are exposed to, there are an astonishing number of symptoms that mast cell activation can produce.
of mast cells in ENL was less than the non-reactional group.
The study increases understanding of how mast cells are formed and could be important in the development of new therapies, for example for mastocytosis for which treatment with imatinib/Glivec is not effective.
Spleen mast cells purified by flow cytometry sorting were plated on 24-well chamber slides and fixed with paraformaldehyde for 30 min.
Mastocytosis represents a spectrum of clinical disorders with a common phenotype of tissue mast cell hyperplasia.
Prevalence and importance of internal tandem duplications in exons 11 and 12 of c-kit in mast cell tumors of dogs.
Education related with use of epinephrine autoinjector in case of sudden hypotension which is observed as a result of acute degranulation of mast cells should be given.
Characteristics of Bone Marrow Mast Cells and Their Exosomes.
11 In Toluidine Blue-stained sections, the most intense areas of mast cells were examined under HPF, and under 10HPFtotal number of mast cells at lamina propria was recorded.
The number of mast cells that was present in 10 consecutive high-power fields (hotspots) was counted in all sections.
Histamine released by degranulation of mast cells can also be measured within 5-10 minutes, but remains elevated for only 30-60 minutes and therefore has very limited value.
It is also proposed that nitric oxide synthase may also protect mast cells from activation induced cell death.