matrix metalloproteinase

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matrix metalloproteinase

[¦mā·triks mə‚tal·ō′prō·tē·ə‚nās]
(biochemistry)
Any member of a family of at least 19 structurally related zinc-dependent neutral endopeptidases collectively capable of degrading essentially all components of extracellular matrix.
References in periodicals archive ?
The matrix metalloproteinases (MMPs) play an important role in the process of cardiac remodeling by regulating structural integrity of the extracellular matrix.
Matrix Metalloproteinases in Health and Disease: Sculpting the Human Body
Matrix metalloproteinases play critical roles in brain function and disease that have only recently received intensive study, said Dr.
Extracellular matrix metalloproteinases - MMPs, also referred to as matrixines, provide a group of proteolytic enzymes.
The elevation of cortisol inhibits fibroblast function and increases matrix metalloproteinases (collagenase, gelatinase).
Reduced matrix metalloproteinases (MMPs) activity is accompanied with extracellular matrix (ECM) accumulation in large arteries, leading to the hypertensive arterial remodeling in resistance arteries.
14,15) The proteins encoded by TIMP gene family are natural inhibitors of matrix metalloproteinases.
1 The production of inflammatory and pro-inflammatory mediators2 and matrix metalloproteinases (MMPs)3 are increased during exercise activity.
This event is mediated by the action of matrix metalloproteinases (MMPs), a family of [Zn.
Matrix metalloproteinases (MMPs) are proteolytic enzymes that cleave almost all components of the extracellular matrix (ECM) including fibronectin, laminin, proteoglycans, type IV collagen, and tight junction proteins (TJP) and have been related to blood-brain barrier (BBB) opening and neurodegeneration associated with ischemia and neuroinflammation [1-4].
The matrix metalloproteinases or matrixins (MMPs) are members of the large metzincin superfamily such as the astacins, serralysins, reprolysins, and adamalysins or disintegrin metalloproteinases (ADAMs).
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