Megakaryocytes


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Related to Megakaryocytes: bone marrow, Lymphocytes

Megakaryocytes

 

in mammals and man, large cells (up to 40 microns) in the hemopoietic organs. Mature megakaryocytes have a multilobed polyploid nucleus. The cytoplasm has a characteristic granularity. Megakaryocytes form thrombocytes.

References in periodicals archive ?
In patients with essential thrombocytemia characterized by thrombocytosis associated with impaired mpl expression in both platelets and megakaryocytes, TPO was within the reference interval or increased (25-27), confirming that the TPO concentration is regulated mainly by mpl in megakaryocytes.
Semiquantitative results are summarized in Table 1, morphometric and morphologic data of megakaryocytes in Table 2, and clinical and hematologic data in Table 3.
a) Adipose tissue, acute hemorrhage and hemosiderin pigment is seen at left, and hematopoietic tissue, including megakaryocytes, at right (100x).
Maternal ingestion of chlorothiazide diuretics or tolbutamide can have a direct cytotoxic effect on the fetal marrow megakaryocytes.
The relation of thrombokinetics to bone marrow megakaryocytes and to the size of the nucleus in polycythemia vera.
The system is exponentially more efficient in generating megakaryocytes than previous methods," stated Shi-Jiang Lu, Ph.
24) Given the finding that regulation of platelet production under steady-state conditions is aimed at keeping the total platelet mass constant, (24) it is understandable that this can only be achieved when the megakaryocytes produce more smaller or less larger platelets, as is reflected by the retPLTs.
In chronic alcoholic cirrhosis, the thrombocytopenia and platelet functional deficiencies may result from the toxic effects of alcohol on bone marrow megakaryocytes.
Essential thrombocythemia is characterized by uncontrolled proliferation of myeloid lineage cells, especially megakaryocytes, leading to the overproduction of platelets.
Histological examination revealed mature necrotic bone with multiple areas of bone marrow formation, including megakaryocytes.
Platelets are fragment of the large megakaryocytes, produced in the bone morrow under influence of thrombopoetin, a chemical made by the liver and kidney.