Megakaryocytes


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Related to Megakaryocytes: bone marrow, Lymphocytes

Megakaryocytes

 

in mammals and man, large cells (up to 40 microns) in the hemopoietic organs. Mature megakaryocytes have a multilobed polyploid nucleus. The cytoplasm has a characteristic granularity. Megakaryocytes form thrombocytes.

References in periodicals archive ?
Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes. Br J Haematol 1998;101:420-4.
Caption: FIGURE 6: Bone marrow aspirate smear: dysplastic megakaryocyte, 100x magnification megakaryocyte with nuclear hypolobation.
Medda, "Differential expression of MMP2 and MMP-9 activity in megakaryocytes and platelets," Blood, vol.
Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol.
Other differential diagnoses may include extensive pyelonephritis with inflammation extending into the perinephric tissues or other inflammatory masses, but these would lack the megakaryocytes seen in EM and EH.
In some patients, megakaryocytes are increased in number and have abnormal ultrastructure.
DNA content and nuclear size of megakaryocytes in thrombocythaemia.
In this way mature megakaryocytes produce platelets and release them into the blood circulation to maintain constant platelet counts.
Evidence for a theory of physical fragmentation of megakaryocytes, implying that all platelets are produced in the pulmonary circulation.
(41,42) Accumulating evidence indicates that the 50 untranslated region mutations cause ANKRD26 overexpression because of defective inhibitory regulation of RUNX1 and FLI1, and this leads to disruption of the thrombopoietin/myeloproliferative leukemia virus oncogene pathway, which is important for platelet formation by megakaryocytes. (41,43) Mutations in the ANKRD26 coding region are less common but also induce ANKRD26 overexpression through a mechanism independent of RUNX1/FLI1 interaction.
(12) reported that the bone marrow biopsy performed on 12 patients with prolonged thrombocytopenia after PSCT revealed the absolute number of megakaryocytes to be lower than normal; Zhang et al.
Megakaryocytes of the bone marrow introduce pseudopodia through the walls of the sinusoids.