Besides medication, foods can alter the parameters, so bone marrow aspiration is better than biochemical profiles for estimation of megaloblastosis
(a known side effect of HU) has been postulated to play a role, too, as the enlarged red blood cells circulate less easily in small blood vessels (3),(10).
Other features noted in bone marrow in HIV patients include numerous bare megakaryocyte nuclei, polymorphic lymphoid aggregates, gelatinous degeneration, deteached nuclear fragments in granulocytes and giant metamyelocytes in the absence of megaloblastosis
ParamePParameters CaseCase 1 CaseCase 2 Cellularity Hypercellular for Tiny particles; age normocellular M:E ratio 1:1.8, mild 15:1 megaloblastosis
Megakaryocytes Decreased Not observed Diff.