megaloblast

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megaloblast

[′meg·ə·lō‚blast]
(pathology)
A large nucleated erythroblast appearing in bone marrow in vitamin B12 or folic acid deficiency.
References in periodicals archive ?
The earliest sign of folic acid or vitamin [B.sub.12] deficiency is a megaloblastic anemia - so-called because of the abnormal production of megaloblasts, the precursors of mature red cells.
Megaloblastic Anaemia- Megaloblasts, Giant Stab and Metamyelocyte in BM Aspirate (100x)
The bone marrow aspiration of megaloblastic anaemia showed numerous megaloblasts with large cells with an increased nuclear/cytoplasmic ratio, sieve-like chromatin and giant metamyelocytes (Figure B).
MA had typical megaloblasts with sieved chromatin and asynchronic nuclear-cytoplasmic maturation (Figure 1).
Deficiency of either vitamin may lead to a type of anaemia in which large, abnormal red blood cells (megaloblasts) overcrowd in the bone marrow, preventing the production of normal red blood cells.