The earliest sign of folic acid or vitamin [B.sub.12] deficiency is a megaloblastic anemia - so-called because of the abnormal production of megaloblasts
, the precursors of mature red cells.
Megaloblastic Anaemia- Megaloblasts
, Giant Stab and Metamyelocyte in BM Aspirate (100x)
The bone marrow aspiration of megaloblastic anaemia showed numerous megaloblasts
with large cells with an increased nuclear/cytoplasmic ratio, sieve-like chromatin and giant metamyelocytes (Figure B).
MA had typical megaloblasts
with sieved chromatin and asynchronic nuclear-cytoplasmic maturation (Figure 1).
Deficiency of either vitamin may lead to a type of anaemia in which large, abnormal red blood cells (megaloblasts
) overcrowd in the bone marrow, preventing the production of normal red blood cells.