Histological analysis of the MCs-seeded compound graft showed a single layer of mesothelium
formed on the outer surface of the tissue tube after incubation for 7 days (Figure 2(e)).
To evaluate healing of the peritoneal mesothelium
, which plays an important role in abdominal adhesion formation, we used immunohistochemistry to determine the expression of cytokeratin in the peritoneal mesothelial cells of the different groups.
Several barrier materials have been used clinically, including hyaluronic acid, carboxymethyl chitin, and oxidized regenerated cellulose, to prevent adhesion by separating the wounded tissues and promoting the repair of mesothelium
Although many theories have been proposed to describe how the ovarian mesothelium
could undergo metaplasia and dysplasia, perhaps the greatest gap in understanding the process of ovarian carcinogenesis from ovarian surface epithelium (OSE) is the recognition of a true precursor lesion of high-grade carcinoma in the ovary.
Although the pathogenesis is poorly understood, it is postulated that these tumours develop through serous or mucinous metaplasia of preexisting coelomic mesothelium
. Surgical excision remains the mainstay of successful management.
It has been shown that under normal circumstances, mesothelin is present in several human tissues, including the mesothelium
and is aberrantly expressed mainly by MM but also by pancreatic cancer, ovarian cancer or some breast and lung cancers [7,12,19].
It is a proliferation of mesothelium
cells of the peritoneum, with a predilection for the pelvic viscera .
Most tumors are benign and, contrary to previous beliefs, they do not derive from the mesothelium
but rather from dendritic interstitial cells, which express CD34 and have generalized distribution in tissues, a feature that helps to recognize them in other organs [2, 3].
It is significantly expressed by most ovarian epithelial tumors but also by the normal epithelium of the female reproductive system, gastrointestinal mucosal cells, and the luminal surface of mesothelium
lining the peritoneum, pleura, and pericardium.
Mesothelioma is a cancerous tumour of the mesothelium
, the lining of some of the major organs.
The surface mesothelium
of normal serosa is derived from multipotent subserosal cells in the underlying layer of connective tissue.
Mesothelioma is an aggressive form of cancer that occurs in the mesothelium
, the thin layer of tissue that covers the lungs and other organs.