meta-analysis

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Related to Metaanalysis: Systematic review

meta-analysis

a method by which the results of a number of quantitative studies can be analysed together to produce an overall impression from a field of research. This method lays emphasis on EFFECT SIZE as well as providing a SIGNIFICANCE TEST for the results. It has advantages over a conventional review in that it forces the analyst to evaluate the method and the results of a study more critically and that it provides an objective method for synthesizing the results from such studies. There are two basic approaches to meta-analysis. The first and most common approach involves combining the results from the studies in order to produce a single effect size, inferential statistic and probability. The second approach involves comparing studies which differ over some aspect of their method to see if the results of studies which utilized one design or measure differ from the results of studies employing a different design or method. By combining the results of a number of studies, meta-analysis can circumvent the problems of low STATISTICAL POWER which may characterize the individual studies. (See Cooper; 1998; Cooper and Hedges, 1994; Rosenthal, 1991)
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Results from this metaanalysis support the hypothesis that consumption of vegetables and fruits could reduce the risk of stroke.
The metaanalysis of the 107 MTHFR studies (86 previous publications reporting on 88 studies (1) and the 19 new ones) that compared IHD risk in TT and CC individuals (76 792 individuals with IHD and 109 818 unaffected controls) yielded an odds ratio of1.07 (95% CI, 1.02-1.13; P = 0.006), suggesting an effect in at least some studies that, with the necessary environmental interactions, have a material difference in homocysteine levels between TT and CC individuals.
The metaanalysis included studies that used a range of interventions, from individual cognitive-behavioral therapy, to family format, to group therapy (psychoeducation).
We conducted a metaanalysis of all eight case-control studies published between 1994 and 2005 of prenatal multivitamin supplementation and pediatric cancer rates, comparing the rates of cancer in their children with matched controls whose mothers did not use supplements.
At the upper limb, the metaanalysis showed a difference of 6.38 mg/[cm.sup.2] at the end of trials and 6.3 mg/[cm.sup.2] after supplementation was stopped, a statistically significant increase of 1.7 percentage points over control populations.
The metaanalysis "confirms that aspirin works, producing a moderate but consistent 10% reduction in important outcomes," said Dr.
Ideally, data should be made available in a way that allows reanalysis and, where appropriate, metaanalysis. Metaanalysis of single hospital studies is no substitute for good multicenter studies, but it could be used to provide some evidence of reproducibility and thus to prioritize targets for definitive trials.
The present study is somewhast different from traditional forms of metaanalysis [1,13] in not comparing results addressing a single question.
Some of the potential challenges and pitfalls associated with metaanalysis are examined, and their consequences are considered.
Christensen was principal investigator in one of the randomized trials included in the metaanalysis (Osteoarthritis Cartilage 2005;13:20-7).
Under the EU-LAR system of grading evidence-based medicine, the new metaanalysis ranks as level 1A evidence supporting the benefit of weight loss in obese knee OA patients.
Now, a metaanalysis has indicated that stimulant therapy inhibits both weight gain and expected height gain.