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Related to Metastatic cancer: metastatic lung cancer


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
Identify and understand important and diverse types of therapeutics under development for Metastatic Cancer.
Our first test, the CancerTYPE ID[R] molecular cancer classifier, predicts the tumor type in patients with metastatic cancers of unknown or uncertain origin.
The findings were alarming--in 31% of the comparisons, the genetic composition of the metastatic cancer cells differed almost completely from that of the primary breast tumors
The CancerTYPE ID[TM] test may decrease the diagnosis time--often four to six weeks or more in standard practice--for a patient with metastatic cancer.
Metastatic cancer is a returning cancer that spreads primarily into four areas: the brain, lungs, bones and liver.
Serum Thyroid Antibody Levels Healthy Cancer Patients Controls Nonmetastatic Metastatic (n=34) (n=16) (n=30) Antithyroperoxidase (IU/mL) 78 68 14 Antithyroglobulin (IU/mL) 103 135 23 Note: Values for nonmetastatic and metastatic cancer patients were significantly different from controls, P < .
A 37-year-old white man was transferred to our institution for palliative radiation therapy for metastatic cancer that involved the lower vertebrae and threatened to compress the spinal cord.
Why is it a news flash that someone with widely metastatic cancer that has been treated is dying now?
Frequent fish consumption may help fend off prostate cancer, especially metastatic cancer, according to data from nearly 48,000 men.
Now, in the largest and longest study of its kind, urologists at Johns Hopkins have developed a simple method for assessing the risk these men have for developing deadly metastatic cancer.
Thus, bone provides a fertile micro-environment which facilitates colonization of metastatic cancer cells," Yoneda explains.
M2 EQUITYBITES-January 26, 2018-Alligator Bioscience hires Theradex Oncology as Clinical CRO for the planned ATOR-1015 Phase I Study in metastatic cancer