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Related to Metastatic disease: multiple myeloma, myeloma, metastases


1. Pathol the spreading of a disease, esp cancer cells, from one part of the body to another
2. a rare word for metabolism



a secondary pathological focus arising from the transfer of a pathogenic principle (tumor cells, infectious agent) from the primary site of affection by the lymph or blood.

In the modern view, the term “metastasis” generally applies to the spread (dissemination) of malignant tumor cells; the spread of an infectious principle is usually described by the term “metastatic infectious focus.”

Benign tumors are also known to metastasize, and the capacity to do so is inherent in normal cells of various origin (in placental villi, adipose and hematopoietic bone-marrow cells). A distinctive feature of metastasizing tumor cells is the uncontrollable growth of the metastasis, relating it to primary foci of malignant growth. Metastatic tumor nodes retain other properties of primary tumors as well, such as microstructural features and the capacity to form the same products; however, metastatic nodes often have a more primitive structure and consist of functionally less mature cells than do the original tumors.

When tumor cells spread chiefly through the lymphatic vessels, metastases generally appear in the lymph nodes closest to the primary site. Although much research has been devoted to the routes and anatomical patterns of lymphogenous metastasis, the biological patterns of formation of lymphogenous metastases remain obscure. The mechanisms of hematogenous metastasis (to the lungs, liver, bones, and other viscera) are better understood. Four stages in the development of hematogenous metastasis are distinguished: (1) the detachment of cells from the primary tumor node and their penetration of the blood through the vascular wall; (2) the circulation of the tumor cells in the blood; (3) the attachment of the cells to the vascular wall and the start of intravascular growth; and (4) the rupture of the vascular wall by the tumorous masses and the subsequent growth of the metastasis into the tissue of the affected organ. The presence of metastasis indicates that a tumorous process has shifted from a local growth phase to a phase of generalization. A distinction is made between solitary metastasis, which generally can be removed surgically, and multiple metastases, which require combined treatment using radiation and chemotherapy.



Transfer of the causal agent (cell or microorganism) of a disease from a primary focus to a distant one through the blood or lymphatic vessels.
A transition of an electron or nucleon from one bound state to another in an atom or molecule, or the capture of an electron by a nucleus.
References in periodicals archive ?
In addition to metastatic disease, acute invasive fungal sinusitis is an important clinical problem that should be considered when constructing a differential diagnosis for the immunocompromised patient, such as a patient with cancer.
presented case of an asymptomatic 61-year-old male who presented with hypercalcemia, and he was found to have extensive lesions in bones, lungs, and lymphadenopathy mimicking extensive metastatic disease. However, biopsy of left iliac crest and peripheral lung biopsy with epithelioid granulomas confirmed the diagnosis of sarcoidosis [12].
The median follow-up time since recurrent or metastatic disease was 8.2 years.
To get a clearer picture of the prevalence of advanced breast cancer in the United States, they worked backward from Surveillance, Epidemiology, and End Results data on breast cancer deaths and survival, working on the assumption that each observed breast cancer death is the result of metastatic disease, either in women whose initial diagnosis was stage IV disease (de novo metastatic disease) or disease recurrence with metastases.
In the past years, there have been significant breakthroughs in the treatment of liver metastatic disease, and multiple nonresection methods have been introduced.
It is associated with high mortality due to the potential for wide spread metastatic disease. Once metastatic disease has occurred, prognosis is very poor with a mean survival rate of approximately 8.4 months [5].
Metastatic disease was reported according to criteria as specified by the World Health Organization (WHO).
Imaging which adds value to the surgical planning may also reveal atypical features and metastatic disease. Because of the indolent nature and low malignant potential of these neoplasms, surgical resection for cure is the treatment in patients with or without metastatic disease.
The clinical presentations of these cases vary; however, the most common method of discovery was the incidental finding of metastatic RCC in the orchiectomy pathology.6 The rarity of RCC spreading to the testis presents a unique challenge of accurately recognizing metastatic disease. As in our case, patients are often incorrectly assumed to have independent testicular disease.
Each day in Canada, more than three women will receive their first breast cancer diagnosis of locally advanced and/or metastatic disease. (4) Metastatic breast cancer is currently considered an incurable disease that may be controlled through treatment, though survival rates remain low.
"Metastatic breast cancer may be a devastating disease, but that does not change the fact that the many Canadians living with metastatic breast cancer are still vibrant members of our society with families, careers, hobbies and everything else that life is about." Each day in Canada, more than three women will receive their first breast cancer diagnosis of locally advanced and/ or metastatic disease. (4) Metastatic breast cancer is currently considered an incurable disease that may be controlled through treatment, though survival rates remain low.
(1,2) Metastatic disease, in particular, is responsible for the vast majority of cancer deaths.

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