We will determine the biological function of the mrna cap methyltransferases
in cd8 t cell survival and activation using immunological assays.
The company is developing a unique platform to address these enzyme classes, including RNA methyltransferases
The same goes for molecules called DNA methyltransferases
, which are important for regulating how genetic instructions are read and acted upon.
Their topics include enzyme and protein families that regulate histone modification and cross-talk, targeting DNA methylation, targeting histone lysine methyltransferases
in cancer, developments if targeting epigenetic readers, who will benefit from epigenetic drugs, histone methyltransferase
activity assays, and safety considerations for epigenetic mechanisms as drug targets: whether existing toxicology studies are fit for the purpose.
Exogenously acquired 16S rRNA methyltransferases
found in aminoglycoside-resistant pathogenic Gram-negative bacteria: an update.
Dysregulation of histone methylation patterns is observed in a variety of human cancers, inflammation, and neurodegenerative diseases, validating histone methyltransferases
(HMTs) as an important class of drug targets among biomedical researchers.
Background: Protein arginine methyltransferases
1 (PRMT1) is over-expressed in a variety of cancers, including lung cancer, and is correlated with a poor prognosis of tumor development.
9,10) DNA methyltransferases
, of which three active forms have been identified (DNMT1, DNMT3A and DNMT3B) catalyze DNA methylation.
A new report from BCC Research says increased R&D spending for development of epigenetic tools and assays for Histone Methyltransferases
(HMT) research, HMTs use as biomarkers and targets for diagnostics development and the dmg discovery sector, will "drive tremendous growth" in this market for the foreseeable future.
Alterations of methionine through diet or cell treatment are known to affect the activity of GNMT and DNA methyltransferases
(DNMTs), the enzyme class responsible for the maintenance and de novo catalyzation of methyl groups onto genomic DNA (3, 5, 6).
Bioactive dietary supplements such as green tea polyphenols (GTPs) and sulforaphane (SFN) inhibit DNA methyltransferases
(DNMTs) and histone deacetylases (HDACs), respectively, which are of central importance to cancer prevention.
A recent study in As3mt-knockout mice suggests that unidentified methyltransferases
could be involved in alternative iAs methylation pathways.