Mevalonic Acid

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mevalonic acid

[¦mev·ə¦lan·ik ′as·əd]
(organic chemistry)
HO2C5H9COOH A dihydroxy acid used in organic synthesis.

Mevalonic Acid


3,5-dihydroxy-3-methyl-valeric acid, an important intermediary product of metabolism. Colorless water-soluble crystals. Melting point, 27°C; readily undergoes dehydration to form the corresponding 8-lactone (mevalolactone):

Physiologically active mevalonic acid is a ( + )-isomer. Mavelonic acid was discovered and isolated by American microbiologists (C. Folkers and others) in 1956. It is widely distributed in plants and animals.

The biosynthesis of mevalonic acid takes place in the microsomes of cells, with participation of three acetyl radicals. The resulting product of condensation undergoes irreversible reduction to mevalonic acid, which means that the latter may be regarded as a specific biogenetic unit. In nature, mevalonic acid is the initial material for the creation of a broad class of natural compounds, the isoprenoids. Synthetic mevalonic acid with an isotopic tag is widely used in studying the biosynthesis of various isoprenoids in organisms, as well as in acellular systems.


Comfort, J. “Biosintez terpenoidov.” Uspekhi khimii, 1969, vol. 38, no. 5. (Article translated from English.)
“Natural Substances Formed Biologically From Mevalonic Acid.” Biochemical Society Symposium, no. 29, Liverpool, April 1969. London-New York, 1970.


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Abrogation of insulinlike growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways.
Diagnosis is based on genetic testing and elevated mevalonic acid levels in urine.
Lupeol and sitosterol are distributed in plant kingdom, which their biosynthesis is via the mevalonic acid pathway.
5) During attacks, urinary excretion of mevalonic acid increases, and measurements have diagnostic value.
They are mainly synthesized by polymalonate, shikimic acid and mevalonic acid pathways (Boustie and Grube, 2005).
They can even be moieties of central metabolites, such as citric and mevalonic acid, which are processed by nearly universal metabolic pathways.
2004), the deficiency of P in the vegetable tissue of a plant may reduce the phosphorylation of mevalonic acid, which means the initial step for the synthesis of isopentenyl pyrophosphate, through the classical route of mevalonate synthesised from acetyl coenzyme A, the main precursor of monoterpenes, such as citral and limonene (Bruneton, 1991; Lange et al.
They are usually synthesized in the leaves, stored in extracellular spaces between the cuticle and the cell wall, and basically constituted by terpenes, synthesized by the mevalonic acid route.
d T cells and genes in the GAS mevalonic acid synthesis pathway responsible for production of isopentenyl-pyrophosphate, a short-chain phospholipid that stimulates these T-cells.
The pleiotropic effects of statins are mainlyowed to the inhibition of metabolic pathway of mevalonic acid.
Identification of Farnesol as the Non-Sterol Derivative of Mevalonic Acid Required for the Accelerated Degradation of 3-hydroxy-3-Methylglutaryl-Coenzyme A Reductase," J.
combinations of mevalonic acid and lycopene or related compounds).