Indeed, Ko said, research has shown that about 4% to 6% of those studied developed microcephaly
, many with abnormally small heads and partly collapsed skulls, eye problems, hearing problems, issues with joints and muscles, and severe developmental issues.
In his study, researchers have shown that the risk of giving birth to a child with microcephaly
might be associated with how the immune system reacts against the virus specifically what kind of antibodies it produces.
Recently a compound heterozygous mutations c.731 C > T (p.Ser 244 Leu) and c.2413 G > T (p.Glu 805 X) in the WDR62 gene responsible for the mitotic centrosomal protein WDR62, in a microcephaly
family from Japanese.3 We have also reported in our recent study a missense mutation in exon 30 of WDR62changing alanine to aspartate in the protein leading to the typical MCPH2 phenotype.4 Whereas new homozygous splicing variantc.3335+1G>C in the WDR62 gene also reported recently.5 Previously pathogenic mutations reported in WDR62 include missense (e.g.
Recent research with Brazilian children with microcephaly
revealed that there is a slight delay in dental eruption, with the first teeth erupting at around 12.3 months of age (3).
On February 1, 2016, the World Health Organization (WHO) declared a Public Health Emergency of International Concern, in response to reported cases of microcephaly
and neurological disorders and their possible association with Zika virus infection.
Autosomal recessive primary microcephaly
(MCPH) is a genetically heterogeneous neurodevelopmental disorder with a prevalence of 1.3 to 150 per 100 000 births depending on the level of consanguinity and ethnicity.
These findings suggest that Zika virus was the causative agent of this case of microcephaly
. PW3 had a maculopapular rash without fever or conjunctivitis and received a Zika virus diagnosis at 20 weeks' gestation.
Among the 1,386 (96%) children who did not have microcephaly
detected at birth, 822 (59%) received neuroimaging, including 14 (2%) who had at least one brain anomaly identified.
Keywords: Autosomal recessive primary microcephaly
, genotyping and ASPM.
Of the 30 women who gave birth to infants with microcephaly
, 24 (80%) had Zika virus infections, compared with 39 of the 61 women (64%) in the control group (P = .12).
A (http://www.dshs.texas.gov/news/releases/2016/20160809.aspx) news release issued by the Texas Department of Health indicated that the state's first case of microcephaly
(a neurological (http://www.mayoclinic.org/diseases-conditions/microcephaly/basics/definition/con-20034823) condition which causes congenital abnormalities and developmental issues) linked to the mosquito-borne Zika virus had also been reported in Harris County.
The virus has been linked to a spike in cases of microcephaly
, a condition in which babies are born with abnormally small heads and possible neurological damage, sparking international concern.