Using a process in which
microdialysis tubing is inserted into a rat brain through the pineal gland, the researchers collected a sample that was analyzed for -- and confirmed -- the presence of DMT.
Microdialysis will be used to measure gepotidacin levels in tissue following surgery and pbpk, poppk and pkpd models will be built to understand the tissue penetration of gepotidacin to characterize exposure response and to evaluate different dose regimens.
The study showed VEGF-A protein post injection of AZD8601 was increased above the pre-specified expected threshold, as measured by skin
microdialysis.
Noteworthy posters include: Modulation of adenosine levels in the tumor microenvironment following treatment with anti-PD1 antibodies and oxaliplatin: an in vivo
microdialysis study: Utilizing in vivo
microdialysis, a technique that has been prominent in neuroscience research for over 50 years, Charles River researchers monitored oncometabolites and immunomodulators directly in the tumor microenvironment.
Microdialysis allows soil to be sampled with minimum disturbance, quantifying fluxes rather than static pools and preventing rapid degradation of the samples collected (Inselsbacher et al 2011; Inselsbacher and Nasholm 2012).
Lactate uptake by the injured human brain: Evidence from an arteriovenous gradient and cerebral
microdialysis study.
Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside
microdialysis. Stroke 2003; 34: 1382-8.
Ipsilateral hippocampal glucose metabolism and glutamate levels were measured in vivo by
microdialysis before, during, and after fornix DBS treatment.
In a study searching for the role of secretoneurin, it was demonstrated that local infusion of secretoneurin by
microdialysis into the striatum and nigra led to increased release of glutamate, GABA and dynorphin B (33).
The published data show that one week after MANF treatment, there was an increased release of dopamine, as well as increased dopamine turnover, in the rat striatum in response to stimulus, as measured by brain
microdialysis.
Some methods used to measure neurotransmitters such as dopamine in addition to carbon fiber micro/nanoelectrodes include positron emission tomography (PET), genetically encoded fluorescent sensors, and
microdialysis. Carbon electrodes can be used to detect dopamine on a relatively fast time scale, but they often cannot detect basal levels of neurochemicals or many analytes simultaneously.
Missing, however, is a thorough comparison of the performance of these two analytical methods in the detection and analysis of PHT in different body compartments (i.e., blood, saliva, and samples from brain tissue
microdialysis).
