Microglia


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to Microglia: Astrocytes, Oligodendrocytes

microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
"We also conducted experiments where we combined nerve cells from healthy individuals and diseased microglia, and vice versa, and could conclude that the excessive pruning in the disease models was due to both a disrupted function of microglia and aberrations in the synapses," says Jessica Gracias, doctoral student at the Department of Physiology and Pharmacology, Karolinska Institute, and co-author of the study.
As part of the study, the researchers used mice prone to developing amyloid plaques and modified in various ways their TREM2 genes to influence the activity of their microglia. The result was four groups of mice: two with fully functional microglia because they carried the common variant of either the human or mouse TREM2 gene, and two with impaired microglia that carried the high-risk human TREM2 variant or no copy of the TREM2 gene at all.
"As human iPSC derived-cells provide a more relevant biology than current animal models in preclinical trials, iCell Microglia can help researchers gain a greater understanding of the nature of neurological diseases, and how to treat the diseases."
Communication between neurons and microglia in the retina is going on all the time.
With this technology, FCDI intends to develop an iPSC-derived microglia product with media, which will be critical to enabling the study of degenerative neurological diseases such as Alzheimer's disease.
Although some studies have examined how byproducts from organisms living in the gut may promote inflammation in the brain, the current study is the first to report on how microbial products may act directly on microglia to prevent inflammation.
has formed a research collaboration with Boston, Massachusetts-based academic medical center Boston University School of Medicine (BUSM) to study the effects of Alzheimer's disease-associated genetic variants on the behavior of brain cells, called microglia, the company said.
Tsirka, "Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage," Neurocritical Care, vol.
Although many studies have reported the effects of BM-MSC transplantation in animal models of brain disease in reducing neuroinflammation induced by microglia [15, 18, 19], the underlying mechanisms of BM-MSCs in targeting microglia-mediated neuroinflammation and the cellular network of activated microglia are still unclear.
Microglia in the CNS originates from cells of mesodermal lineage.