Microglia

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microglia

[mī′kräg·lē·ə]
(neuroscience)
Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.

Microglia

 

mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

References in periodicals archive ?
Chiba, "Diversity and plasticity of microglial cells in psychiatric and neurological disorders," Pharmacology and Therapeutics, vol.
In the present study, we explored the signaling-based mechanisms of the anti-inflammatory effects of RJ in microglial cells. First, we used LPS at 1 [micro]g/mL to simulate BV-2 cells and observed that the phosphorylation levels of I[kappa]B[alpha], JNK, p38, and ERK peaked at 45 min.
The process of attenuation was mediated through modulation of inflammation, brain water content, improving tight junction proteins, microglial cell activation, and oxidative damage.
To test the feasibility of the self-referencing technique for the detection of ROI from single microglial cells, we activated the NADPH oxidase machinery with phorbol-12-myristate-13-acetate (PMA), a potent activator of this enzyme (6).
Helmchen, "Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo," Science, vol.
Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-[kappa]B and p38/JNK activation in microglial cells. Neurochemistry International 62, 913-921.
The remaining adherent cells (i.e., microglial cells) were left to replicate further (2-3 weeks) in the 24-well plate (Nunc Thermo scientific, Leicestershire, UK).
At 24 hr after IT DEP administration, immunohistochemical analysis showed that DEP up-regulated IBA-1 on microglial cells, without obvious differences in morphology or cell number (Figure 3), a response similar to microglial activation previously observed in response to systemic LPS administration (Qin et al.
Rapamycin treatment inhibits the hypoxia induced expression of inducible NO synthase in microglial cells (100).
The microglial cell model murine microglial cell line N9 was used [28].
How much of the changes in D-serine level during aging are determined by microglial cell actions has not been elucidated.