origin and phenotypes in health and disease.
Chiba, "Diversity and plasticity of microglial cells
in psychiatric and neurological disorders," Pharmacology and Therapeutics, vol.
In the present study, we explored the signaling-based mechanisms of the anti-inflammatory effects of RJ in microglial cells
. First, we used LPS at 1 [micro]g/mL to simulate BV-2 cells and observed that the phosphorylation levels of I[kappa]B[alpha], JNK, p38, and ERK peaked at 45 min.
The process of attenuation was mediated through modulation of inflammation, brain water content, improving tight junction proteins, microglial cell
activation, and oxidative damage.
To test the feasibility of the self-referencing technique for the detection of ROI from single microglial cells
, we activated the NADPH oxidase machinery with phorbol-12-myristate-13-acetate (PMA), a potent activator of this enzyme (6).
Helmchen, "Resting microglial cells
are highly dynamic surveillants of brain parenchyma in vivo," Science, vol.
Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-[kappa]B and p38/JNK activation in microglial cells
. Neurochemistry International 62, 913-921.
The remaining adherent cells (i.e., microglial cells
) were left to replicate further (2-3 weeks) in the 24-well plate (Nunc Thermo scientific, Leicestershire, UK).
At 24 hr after IT DEP administration, immunohistochemical analysis showed that DEP up-regulated IBA-1 on microglial cells
, without obvious differences in morphology or cell number (Figure 3), a response similar to microglial activation previously observed in response to systemic LPS administration (Qin et al.
Rapamycin treatment inhibits the hypoxia induced expression of inducible NO synthase in microglial cells
The microglial cell
model murine microglial cell
line N9 was used .
How much of the changes in D-serine level during aging are determined by microglial cell
actions has not been elucidated.