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Small neuroglia cells of the central nervous system having long processes and exhibiting ameboid and phagocytic activity under certain pathologic conditions.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



mesoglia, small rounded cells in the central nervous system.

Microglia develop from cells of connective tissue and constitute about 10 percent of the total number of cells of the neuroglia. Each microglial cell is connected by branching processes with the neuron-neuroglia system and the brain capillaries. The number and size of the microglial cells increase with infections, intoxications, or brain edema. The cells perform a phagocytic role, removing necrotic sections of nerve tissue.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The Influence of Biphalin on MOP Expression in Vehicle- and LPS-Treated Microglial Cells. The level of MOP receptor was not modulated after LPS treatment compared to controls (Figure 8(a)).
Streit, "Evidence that aging and amyloid promote microglial cell senescence," Rejuvenation Research, vol.
Finally, we assessed the ability of HBA and PCA to attenuate LPS-induced inflammation in the BV2 microglial cell line.
It stimulates microglial cells to release pro-inflammatory molecules and accumulate free radicals.
After 24-hr exposure, microglial cells were fixed with 4% paraformaldehyde (15 min at room temperature) followed by 0.2% Triton (10 min at room temperature).
When the scientists injected the mice with an antibody against the A-beta protein, prompting the rodents to produce fewer plaques, the microglial cells resumed their normal functions.
In addition, our in vitro data also showed that silymarin inhibited LPS-induced NF-[kappa]B activation/nuclear translocation in microglial cells, indicating that silymarin suppressed NO production or inflammatory-related genes via the NF-[kappa]B-dependent mechanism.
As shown in Figures 3 and 4, there were significantly more microglial cells in the hippocampal dentate gyrus of the model and puerarin groups (P<0.01), as well as in the cortex (P<0.05 and P<0.01, respectively) compared with the control group.
Smith, "Highly permissive infection of microglial cells by Japanese encephalitis virus: a possible role as a viral reservoir,' Microbes and Infection, vol.
(a) SOCS1siRNA was effective in reducing SOCS1 protein expression in N9 microglial cells. The N9 microglial cells were divided into three groups as shown in the figure.
Ford, "Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway," Journal of Neuroinflammation, vol.
A study demonstrated that in BV2 microglial cell lines, resveratrol could inhibit NLR family pyrin domain containing 3 (NLRP3) activation and IL-1[beta] cleavage caused by ATP.