There is a correlation between the onset of stiffening and the expression of the
microtubule associated protein DCAMKL1, thus implicating DCAMKL1 in a stress-stiffening-mediated, mechanostransduction pathway that involves microtubule dynamics in the mechanisms underlying stem cell differentiation and commitment to a specific cell lineage.
The C-terminal is made up of two antiparallel helices H11-H12 which interacts with
Microtubule Associated Protein (MAP) (11).
Microtubule associated protein tau is mainly expressed in neurons and it is involved in modulating microtubule assembly and stabilizing the neuronal cytoskeleton [1].
A possible candidate is phagocytosis given that the
microtubule associated protein stathmin is such a strong p38[delta] MAPK substrate.
Conventional PXAs demonstrated immunoreactivity for glial fibrillary acidic protein (100% of cases), S-100 protein (100%), class III [beta]-tubulin (73%), synaptophysin (38%), NF (nuclear factor) proteins (18 and 8%), and MAP2 (
microtubule associated protein 2) (8%).6
Ran GTPase activating protein-1 (RanBPl % and
microtubule associated protein RP/EB family member 1 (EB1) were confirmed by Western blotting.
