There is a correlation between the onset of stiffening and the expression of the microtubule associated protein
DCAMKL1, thus implicating DCAMKL1 in a stress-stiffening-mediated, mechanostransduction pathway that involves microtubule dynamics in the mechanisms underlying stem cell differentiation and commitment to a specific cell lineage.
The C-terminal is made up of two antiparallel helices H11-H12 which interacts with Microtubule Associated Protein
Microtubule associated protein
tau is mainly expressed in neurons and it is involved in modulating microtubule assembly and stabilizing the neuronal cytoskeleton .
A possible candidate is phagocytosis given that the microtubule associated protein
stathmin is such a strong p38[delta] MAPK substrate.
Conventional PXAs demonstrated immunoreactivity for glial fibrillary acidic protein (100% of cases), S-100 protein (100%), class III [beta]-tubulin (73%), synaptophysin (38%), NF (nuclear factor) proteins (18 and 8%), and MAP2 (microtubule associated protein
Ran GTPase activating protein-1 (RanBPl % and microtubule associated protein
RP/EB family member 1 (EB1) were confirmed by Western blotting.