Microtubules


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Microtubules

 

tubular formations in animals and plant cells. The diameter of microtubules, or threads, is 150–290 angstroms (Å), rarely up to 400 Å; the inner diameter is 100–200 Å. The wall of aomicrotubule consists of 7–15, more often 12–13, threads 30–40 Å in diameter, constructed of globular protein subparticles approximately 35 Å in size.

There are two basic kinds of microtubules: cytoplasmic microtubules and those of the spindle of cell division. Cytoplasmic microtubules support the cell and ensure intracellular transport, cell movement, and contraction of the cell and its components. According to some data, cytoplasmic microtubules are active in the construction of microtubules of the spindle of cell division.

References in periodicals archive ?
2E) showed that the microtubules from both poles were not overlapped and were observed like two independent half spindles.
We investigated the impact of microtubule destabilization and dechanneling therapy on a suppression of refractory electrical storm (ES) in a 63-year-old male patient with ischaemic heart failure with reduced left ventricular ejection fraction (HFrEF), who had a history of previous coronary artery bypass grafting and implantable cardioverter-defibrillator (ICD).
MAP4 has been reported to play an important role in the modulation of microtubule dynamics through interaction with septin [12].
In Alzheimer's disease, tau protein loses its ability to bind to the microtubules due to the conformation changes, which lead to aberrant aggregation in the neuron.
White, "Mechanical modulation of cardiac microtubules," Pflugers Archiv European Journal of Physiology, vol.
As the transport of Cx43 is mediated by microtubules, it is phosphorylated and oligomerized into hexameric structures termed connexon [39].
Curcumin, a natural product targeting microtubules, is the most studied dietary phytochemical, which originates from the rhizome of Curcuma longa Linn (Zingiberaceae) (Gupta et al., 2006).
Using live cell and immunofluorescence microscopy, we tested the hypothesis that a central spindle-like organization of microtubules mediated cytokinesis in these ammonia-activated eggs, even in the absence of a canonical, centriole-organized, aster-dominated mitotic apparatus.
Stabilizing microtubules with Taxol causes the formation of elongated, oblique secondary cell wall pits in xylem vessels.
This high potency, small molecule drug binds to microtubules and prevents polymerization which has been shown to not only block cell division and induce cell death, but also disrupts androgen receptor signaling required for tumor growth.
These stride along protein microtubules that form the cell structure.

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