mitochondrial genome


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mitochondrial genome

[‚mīd·ə¦kän·drē·əl ′je‚nōm]
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Key players in the remodelling of the mitochondrial membrane are the mitochondrial genome maintenance protein 1 (Mgm1) in yeats and the optic atrophy protein 1 (OPA1) in humans.
"We noticed that topoisomerase 2 is especially important in the replication of the mitochondrial genome, as it regulates the winding of this small DNA molecule by removing positive twists," Academy Research Fellow Steffi Goffart from the University of Eastern Finland says.
Evolutionary studies give comparison of mitochondrial genome organization and function while molecular studies help in the improvement of these evolutionary studies.
The mitochondrial genome has its own genetic information system that can perform replication, transcription, and translation functions.
The complete mitochondrial genome of Pinctada fucata martensii was 31,435 bp (Fig.
As humanin is encoded within the mitochondrial genome, the research team examined the mitochondrial DNA for common genetic variations known as single nucleotide polymorphisms (SNPs) that could explain the differences between humanin levels.
Once the fragments were sequenced, the team aligned them with giant panda mitochondrial genome reference sequence to recover complete mitochondrial genome of the panda in question.
Using a bone fragment which dates back nearly 13,000 years, scientists teased out and reconstructed DNA fragments to obtain a high-quality mitochondrial genome and nuclear genomic information.
The mitochondrial genome has a higher mutation rate than the nuclear genome; thus, its mutations accumulate during aging [67].
The results obtained by our group suggest, however, that mitochondrial genome mutations can also be associated with myocardial infarction.
"Testing the Mitochondrial genome, which is transmitted exclusively through the female germ line, makes it possible to identify relatives," Rabbi Yosef Carmel, the Rabbinical Dean of the Eretz Hemdah Institute for Advanced Jewish Studies, told the Israeli newspaper Makor Rishon.

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