BAX is a pro-apoptotic member of the BCL2 family , its oligomerization and channel formation caused mitochondrial membrane
permeabilization via inducing cytochrome c release [27,28].
Green fluorescence reflects the monomeric form of JC-1 appearing in the cytoplasm after mitochondrial membrane
Another fusion reduction pathway is provided through ubiquitination, membrane extraction, and degradation of outer mitochondrial membrane
fusion proteins Mfn1 and Mfn2, via proteasomes [80, 81].
Although a variety of cytokines were released from macrophages cultured with different kinds of GBCAs, we acknowledge that the increase in ROS, IL-6, nitrite/nitrate, and PGE2 levels and the decrease in mitochondrial membrane
potential induced by GBCAs in the current study are not analyzed in the clinical practice.
Assessment of Mitochondrial Membrane
Because Bcl-2 inhibits mitochondrial membrane
permeabilization through Bax [56-59], we investigated whether Bcl-2 overexpression alleviates the apoptotic effects of IFN[gamma] and TNF[alpha].
The permeability of mitochondrial membrane
has been shown to play a role in apoptosis.
reported that vitrification changed mitochondrial membrane
potential of human oocytes (63).
The day ended with the awarding of the Tox21 Student Award to Wenyi Wang from Rutgers University for her work titled Mechanistic Evaluation of Chemicals that Induce Oral Acute Toxicity by Mitochondrial Membrane
Disruption: Big Data Profiling and Analysis; the Edward Carney Award for Predictive Toxicology was given to Ellen Garcia from Virginia Tech for her presentation Characterization of two lung cell lines for use in cell division focused, single-cell toxicity assays.
(22-24) The MPTP forms a channel, or pore, through the mitochondrial membrane
In current study we examined the effects of C2 ceramide and ceranib-2 on the potential of mitochondrial membrane
of A549 cells.
The results of ROS and mitochondrial membrane
potential measurement showed that vast ROS were generated in the astrocytes and causing mitochondrial membrane
potential significantly decreased after a prolonged exposure to CO.