mitogen-activated protein kinases

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Related to Mitogen-activated protein kinase: MAP kinase, MAPK

mitogen-activated protein kinases

[‚mīd·ə·jən ¦ak·tə‚vād·əd ¦prō‚tēn ′kī‚nās·əs]
(cell and molecular biology)
A large kinase network in which upstream kinases activate downstream kinases that, in response to phosphorylation, translocate to the nucleus and activate transcription factors. Abbreviated MAPKs.
References in periodicals archive ?
DUSP10 (also known as MKP-5) as DUSP1 refers to the family of phosphatases that regulate the activity of mitogen-activated protein kinases.
Lee, "Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis," Cancer Research, vol.
Immunoblotting was performed with appropriately diluted specific primary antibodies for PI3K (anti-phosphoinositide 3 kinase Mab) and phospho PDK1 (antiphosphoinositide-dependent Kinase 1 Mab) and p38MAPK (anti-p38 mitogen-activated protein kinase Mab) respectively.
Involvement mitogen-activated protein kinase cascade during oocyte maturation and fertilization in mammals.
ERK2 is a mitogen-activated protein kinase (MAPK) involved in cell proliferation, differentiation, survival control and embryonic development.
New therapies on the horizon include agents targeting the inflammatory cytokines interleukins-6, -12, and -15, as well as orally administered small molecules that inhibit Janus kinase, spleen tyrosine kinase, TNF-alpha converting enzyme, or mitogen-activated protein kinase.
Other possible diagnoses in patients with multiple CALMs include familial CALMs (without any other findings) and other neuro-cardio-facial-cutaneous syndromes involving the ras / mitogen-activated protein kinase (ras / MAPK) signaling pathway.
We show that p38 mitogen-activated protein kinase (p38 MAPK) phosphorylates the spliced form of X-box binding protein 1 (Xbp1s) on its Thr48 and Ser61 residues and greatly enhances its nuclear migration in mice, whereas mutation of either residue to alanine substantially reduces its nuclear translocation and activity.
Downstream of TRAF6, mitogen-activated protein kinase (MAPK) is activated and IkBs degraded, finally, activator protein-1 (AP-1) and NF-[kappa]B are activated (19).
HER2 overexpression results in activation of multiple intracellular signalling pathways, including the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) cascades which act to modulate cellular proliferative and survival responses, and tumours overexpressing HER2 have been found to be more aggressive in comparison with tumours that do not.
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