mitogen-activated protein kinases

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Related to Mitogen-activated protein kinase: MAP kinase, MAPK

mitogen-activated protein kinases

[‚mīd·ə·jən ¦ak·tə‚vād·əd ¦prō‚tēn ′kī‚nās·əs]
(cell and molecular biology)
A large kinase network in which upstream kinases activate downstream kinases that, in response to phosphorylation, translocate to the nucleus and activate transcription factors. Abbreviated MAPKs.
References in periodicals archive ?
Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells.
With regard to the regulation of TNF-[alpha], mitogen-activated protein kinases (MAPKs) family including p38 kinase, c-jun N-terminal kinase (JNK) and extracellular signal regulated kinase (ERK) are important mediators.
This is followed by activation of protein kinase C, mitogen-activated protein kinases (MAPKs) and transcription factor nuclear factor-kappa B (NF-[kappa]B) and releasing of inflammatory cytokines (Kalesnikoff and Galli 2008).
Thyroid hormone promotes serine phosphorylation of p53 by mitogen-activated protein kinase.
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.
Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation end transformation in mouse JB6 cells.
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor [kappa]3 through the mitogen-activated protein kinase, extracellular signal--regulated kinase (MEK)/ERK extracellular signal--regulated kinase (ERK) pathway, possibly facilitating the host immune response.
His studies focus on a signaling pathway inside cells that depends upon a protein called mitogen-activated protein kinase (MAPK).
They discovered that the enzyme, called mitogen-activated protein kinase, or MAP kinase, is five to 20 times more abundant in cancerous breast cells than in noncancerous breast cells.
Mitogen-Activated Protein Kinase and Natural Phenolic Compounds in Cardiovascular Remodeling
In addition, RXi announced that it has also received a Notice of Allowance from the USPTO covering the composition and methods of use for rxRNAori compounds targeting Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4).
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