mitomycin

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mitomycin

[¦mīd·ə¦mīs·ən]
(microbiology)
A complex of three antibiotics (mitomycin A, B, and C) produced by Streptomyces caespitosus.
References in periodicals archive ?
Although morphine does not induce formation of micronuclei following in vitro exposure of splenocytes to the drug, incubation of cells with morphine following mitomycin C treatment did produce marked increases in the frequency of micronucleated cells (Table 1).
Mitomycin C forms covalently bound DNA monoadducts and cross-links (Tomasz et al.
In experiments conducted with 4 mM hydroxyurea in the medium, the amount of thymidine incorporation observed was markedly reduced compared to that in its absence, although the relative increase following mitomycin C treatment was similar (data not shown).
Although the assay for measurement of strand breaks employed yields a result that is the net effect of induction of breaks and their reannealing, the increase in DNA breaks due to incision at mitomycin C damaged sites (Table 2) indicates that morphine does not block incision but interferes with a subsequent step in excision repair.
Spleens of rats treated with mitomycin C have been found to have 1 major adduct and 6 relatively minor ones (Reddy and Randerrath, 1987).
Automated analysis of mitomycin C in body fluids by high performance liquid chromatography with on-line sample pre-treatment.
High performance liquid chromatographic determination of mitomycin C in rat and human plasma and urine.
The use of mitomycin C in patients with Meniere's disease was first described by Yazawa et al in 1999.
The mitomycin C group experienced a significantly greater improvement in hearing and no recurrences.
During the past few years, several reports of the effects of mitomycin C on the tympanic membrane and skin have appeared.
21-23) In 2003, Kriukov et al reported good results with mitomycin C in preventing scar formation in tympanic cavities during surgery on patients with suppurative otitis media.