Mucins

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Mucins

secretions from epithelial cells in the mucosa of respiratory, digestive, and urogenital tracts, as well as from the submaxillary and sublingual salivary glands. Mucins are mixtures of the carbohydrate-protein compounds known as glycoproteins and impart moisture and elasticity to the mucosa. Salivary mucins promote the moistening and adhesion of food particles for smooth passage through the esophagus. Covering the gastrointestinal mucosa, mucins provide protection from the action of proteolytic enzymes in gastric and intestinal juices. Mucins perform an overall protective function in the organism; for example, they inhibit the erythrocyte agglutination caused by the influenza virus.

References in periodicals archive ?

Mucins are highly glycosylated proteoglycans produced by goblet cells in the mucosa; the protective mucins are constantly reshaped and refreshed.

The Incredible Gastrointestinal Barrier System and Permeability: Laboratory Assessment and Insights for Intervention

In preclinical studies, the AMPPLIFY Drug Delivery Technology increased delivery of loteprednol etabonate into ocular tissues more than three-fold compared to current LE products by facilitating penetration through the tear film mucins.

Kala Pharmaceuticals New Drug Application for KPI-121 0.25% for Dry Eye Disease Accepted for Review by the US Food and Drug Administration

The scientists homed in on the enzymes the bacteria use to pluck the sugars off mucin and found a new family of enzymes that are 30 times more effective at removing red blood cell antigens than previously reported candidates.

Bloodworks

aeruginosa , is one of the most potent inducers of mucus overproduction.[13],[14] We sought to identify the role of CUR in LPS-induced MUC5AC mucin production, as well as the underlying mechanism.

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2

Immunohistochemical staining of mucins 1, 4, and 5AC in each tissue was independently assessed by two senior pathologists who have been blinded to the clinicopathological data.

Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN)--precursor lesions of pancreatic ductal adenocarcinoma (PDAC)

The presence of mucin in the neuroendocrine component is reminiscent of goblet cell carcinoid.

Coexistence of gastric multiple neuroendocrine tumors with unusual morphological features and gastric signet-ring cell carcinoma

The transitional zone of the prostate gland comprised a macrolobulated heterogeneous hyperintense mass with a hypointense capsule on T2-weighted images (WIs) (Figure 1) The prostatic mass exhibited central and peripherally hyperintense areas within the mass on T1-WIs, compatible with mucin lakes (Figure 2).

Magnetic Resonance Imaging Features of Prostate Mucinous Adenocarcinoma/Prostat Musinoz Adenokanserinin Manyetik Rezonans Goruntuleme Bulgulari

They produce mucin for the lubrication of the intestinal contents and protection of the epithelium.

TIME OF APPEARANCE OF GOBLET CELLS IN HUMAN SMALL INTESTINE

For example, in ovo Thr supplementation increased mucin (MUC2) expression in broiler chickens [6] and quails [7], thus increasing protection of the intestinal mucosa against pathogens and improving digestion and nutrient absorption.

Intra-Amnionic Threonine Administered to Chicken Embryos Reduces Salmonella Enteritidis Cecal Counts and Improves Posthatch Intestinal Development

Macha et al., "Mucins in lung cancer: diagnostic, prognostic, and therapeutic implications," Journal of Thoracic Oncology, vol.

Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

Hollingsworth, "Cell surface-associaed mucins in signal transduction," Trends in Cell Biology, vol.

Mucin-1 Gene Mutation and the Kidney: The Link between Autosomal Dominant Tubulointerstitial Kidney Disease and Focal and Segmental Glomerulosclerosis

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