mucopolysaccharidosis

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mucopolysaccharidosis

[¦myü·kō‚päl·ē‚sak·ə·rə′dō·səs]
(medicine)
Any of several inborn metabolic disorders involving mucopolysaccharides; the six types are MPS I, Hurler's syndrome; MPS II, Hunter's syndrome; MPS III, Sanfillipo's syndrome; MPS IV, Morquio's syndrome; MPS V, Scheil's syndrome; and MPS VI, Maroteaux-Lamy's syndrome.
References in periodicals archive ?
Armand began his career at the University of Chicago in the early 1960's where he was involved in the isolation and structural characterization of heparan sulfate and dermatan sulfate from skin fibroblasts and from urine derived from patients with "Hurler Syndrome ", a form of mucopolysaccharidoses.
2353/W - "MPS Brazil-Network: 4 years improving diagnosis and management of mucopolysaccharidoses in Brazil"
In the case of the mucopolysaccharidoses, a single enzyme defect leads to a block in the sequential degradation of glycosaminoglycans, and the undigested fragments accumulate in the lysosomes, which become distended and gradually compromise cellular function.
Our experience in designing therapies for rare diseases to date will allow us to develop molecules that we believe will appropriately target affected organs for both lysosomal storage disorders and mucopolysaccharidoses.